Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Aim: Maternal vitamin K (VK) deficiency can lead to fetal complications such as cerebral hemorrhage and bone malformations. In this study, we aimed to analyze changes in prothrombin time (PT) and protein induced by VK absence or antagonist II (PIVKA-II) in patients with severe hyperemesis gravidarum with suspected VK deficiency.
Methods: We compared 151 patients with severe hyperemesis gravidarum treated with intravenous nutrition to 46 patients undergoing cervical suturing or benign ovarian tumor surgery before mid-pregnancy.
Results: In the hyperemesis group, coagulation factors, including PT (s), prothrombin activity, INR, and APTT, showed a significant shift toward fibrinolysis compared to control (p < 0.001). The changes were within the normal range, except for PT (s), which was prolonged (14.6 ± 1.4 s). PIVKA-II was measured 25 times in 11 cases of hyperemesis and significantly correlated with PT (s). Moreover, VK was supplemented in four cases with severe VK deficiency, promptly normalizing both PT (s) and PIVKA-II.
Conclusions: Monitoring VK deficiency using PT (s) and PIVKA-II, with timely VK supplementation, may help prevent fetal complications in severe hyperemesis gravidarum.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/jog.16198 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!