The primary objective of the study was to examine associations between financial stress and self-rated health (mental and physical), with presence of and search for meaning in life as moderator variables. The secondary objective was to examine the association between presence of meaning and self-rated health, with search for meaning as a moderator. The sample included 166 emerging adults (ages 18-32, mean age 22.55) recruited from a university setting ( = 87) and online platform ( = 79). To examine the proposed moderating effects, two hierarchical multiple regression models were conducted using secondary data. For the primary objective, presence of meaning did not moderate the association between financial stress and self-rated health (mental or physical). Search for meaning strengthened the negative association between financial stress and physical health, exacerbating the negative health impacts associated with financial stress. However, search for meaning did not moderate the association between financial stress and mental health. For the secondary objective, search for meaning moderated the association between presence of meaning and physical health such that a negative presence-physical health association emerged at high levels of search, and a positive presence-physical health association emerged at low levels of search. Presence of meaning was not a protective factor in the association between financial stress and self-rated health, perhaps because average presence of meaning was lower than average search for meaning in this sample. Search for meaning was a risk factor for adverse physical health when financial stress was high or presence of meaning was low. Future research should examine in which contexts (e.g., different stressors, cultures) meaning in life dimensions emerge as risk versus protective factors.
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http://dx.doi.org/10.1080/07448481.2024.2444655 | DOI Listing |
Psychopharmacology (Berl)
January 2025
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Canada.
Rationale: Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinical literature remains conflicted regarding the underlying neurobehavioral mechanisms, reporting mixed effects of CBD (increased, decreased, or no effect) on anxiety- and fear-related behaviors. Preclinical data demonstrated that CBD modulates hypothalamus-pituitary-adrenal (HPA) axis gene expression; it is unknown whether CBD changes HPA axis responsivity and how this relates to altered behavior.
View Article and Find Full Text PDFAn Pediatr (Engl Ed)
January 2025
Stress and Health Research Group, Autonomous University of Barcelona, Barcelona, Spain.
Objective: To describe the perceived wellbeing (pWB) and the psychological characteristics of young people with life-limiting and life-threatening conditions (LLTCs).
Methods: We conducted a cross-sectional study in young people aged 8 years or older with collection of data on demographic and disease-related variables from the health records. In the psychological evaluation, we collected data on emotion regulation, cognitive strategies and risk of depression and anxiety, in addition to the assessment of the pWB through a visual analogue scale.
Dent Mater
January 2025
Department of Engineering Mechanics, School of Civil Engineering, Wuhan University, Wuhan, Hubei 430072, China; Wuhan University Shenzhen Research Institute, Shenzhen 518108, China. Electronic address:
Objective: Photopolymerized resin composites are widely used as dental filling materials. However, the shrinkage stress generated during photopolymerization can lead to marginal microcracks and eventual restoration failure. Accurate assessment of the stress evolution in dental restorations, particularly in complex cavity geometries, is critical for improving the performance and longevity of the dental filling materials.
View Article and Find Full Text PDFChem Biol Interact
January 2025
Key Laboratory of Environmental Medicine Engineering, Ministry of Education of China, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China. Electronic address:
Copper, as a vital trace element and ubiquitous environmental pollutant, exhibits a positive correlation with the neurodegenerative diseases. Recent studies have highlighted ferroptosis's significance in heavy metal-induced neurodegenerative diseases, yet its role in copper-related neurotoxicity remains unclear. This study aimed to investigate the role of ferroptosis in copper-induced neurotoxicity.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
January 2025
CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL 34987, USA. Electronic address:
Optineurin/OPTN is an adapter protein that plays a crucial role in mediating many cellular functions, including autophagy, vesicle trafficking, and various signalling pathways. Mutations of OPTN are linked with neurodegenerative disorders, glaucoma, and amyotrophic lateral sclerosis (ALS). Recent work has shown that OPTN provides cytoprotection from many types of stress, including oxidative stress, endoplasmic reticulum stress, protein homeostasis stress, tumour necrosis factor α, and microbial infection.
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