In primary care, trigger tools have been utilized to evaluate and identify patient safety events. The use of trigger tools could help clinicians and patients detect adverse events in a patient's medical record. Due to a lack of research on the process development of trigger tools in primary care, the purpose of this scoping review is to investigate the trigger development and validation process in primary care settings. A scoping review methodology was used to map the published literature using the Joanna Briggs Methodology of performing scoping review. We considered only studies published in English in the last five years and included both qualitative and quantitative study designs. The final review included five articles. The primary care and combined primary-secondary care studies are included to gain more knowledge in the process development and validation of trigger tools. The trigger tool development process begins with clearly defining the triggers, which are then programmed into a combined computerized algorithm. The validation process was then carried out in two steps by both physician and non-physician experts for content and concurrent validity. The sensitivity, specificity, and positive predictive value (PPV) of the final algorithm were critical in determining the validity of each trigger. This study provided a comprehensive guide to developing trigger tools, emphasizing the importance of precisely defining triggers through a thorough literature review and dual validation process. There were similarities in the development and validation of trigger tools across primary care and hospital settings, allowing primary care to learn from hospital settings.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308906 | PLOS |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694991 | PMC |
J Mol Model
January 2025
Laboratorio de Química Teórica Computacional (QTC), Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, 7820436, Santiago de Chile, Chile.
Context: Dopamine -monooxygenase (D M) is an essential enzyme in the organism that regioselectively converts dopamine into R-norepinephrine, the key step of the reaction, studied in this paper, is a hydrogen atom transfer (HAT) from dopamine to a superoxo complex on D M, forming a hydroperoxo intermediate and dopamine radical. It was found that the formation of a hydrogen bond between dopamine and the D M catalyst strengthens the substrate-enzyme interaction and facilitates the HAT which takes place selectively to give the desired enantiomeric form of the product. Six reactions leading to the hydroperoxo intermediate were analyzed in detail using theoretical and computational tools in order to identify the most probable reaction mechanism.
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December 2024
Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Background: Alzheimer's disease (AD) hallmarks are amyloid plaques and tau tangles. APOE and TREM2 are the strongest genetic risk factors for AD. Triggering receptor expressed on myeloid cells 2 (TREM2) is increasingly recognized to play a central role in amyloid beta clearance and microglia activation in AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stem Cells, Aging and Neurodegeneration, Lund University, Lund, Lund, Sweden.
Background: Stem cell based models of neurodegeneration are emerging as valuable tools to study neuronal networks as well as for drug discovery and testing. Drugs identified using stem cell based models are now entering clinical trials.
Method: We have generated CHMP2B, APP, PSEN and Tau-mutated and transgenic human embryonic and induced pluripotent stem cell lines, using CRISPR genome editing, with the purpose to create human in vitro disease models.
Alzheimers Dement
December 2024
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Background: Cellular senescence is defined as cell cycle arrest and the acquisition of a proinflammatory 'senescence-associated secretory phenotype' (SASP). In Alzheimer's disease (AD), tau protein in neurons undergoes hyperphosphorylation and misfolding, resulting in the formation of pathogenic soluble aggregates known as tau oligomers. Tau oligomers are released from neurons during neuronal activation and are transmitted to postsynaptic cells in a prion-like fashion.
View Article and Find Full Text PDFPLoS One
January 2025
Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Skudai, Malaysia.
In primary care, trigger tools have been utilized to evaluate and identify patient safety events. The use of trigger tools could help clinicians and patients detect adverse events in a patient's medical record. Due to a lack of research on the process development of trigger tools in primary care, the purpose of this scoping review is to investigate the trigger development and validation process in primary care settings.
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