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Variable surface antigen expression, virulence, and persistent infection by malaria parasites.
Microbiol Mol Biol Rev
January 2025
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
SUMMARYThe human malaria parasite is known for its ability to maintain lengthy infections that can extend for over a year. This property is derived from the parasite's capacity to continuously alter the antigens expressed on the surface of the infected red blood cell, thereby avoiding antibody recognition and immune destruction. The primary target of the immune system is an antigen called PfEMP1 that serves as a cell surface receptor and enables infected cells to adhere to the vascular endothelium and thus avoid filtration by the spleen.
View Article and Find Full Text PDFSplenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand.
Proc Natl Acad Sci U S A
January 2025
Biorheology Research Laboratory, Faculty of Health, Griffith University, Gold Coast, QLD 4222, Australia.
Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series.
Kidney Res Clin Pract
November 2024
Department of Pediatrics, Korea University Ansan Hospital, Ansan, Republic of Korea.
Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions.
Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed.
Splenic Modulation of Plasmodium vivax Relapses and Hypnozoite Activation during the Second World War?
Am J Trop Med Hyg
November 2024
Australian Defence Force Malaria and Infectious Disease Institute, Enoggera, Australia.
Despite their colonial experience with tropical medicine, Allied (United States, United Kingdom, Australia, and India) Armies in the Indo-Pacific region were surprised by the large number of Plasmodium vivax infections in their soldiers during the Second World War. Even after the institution of effective chemoprophylaxis with quinacrine, multiple cycles of clinical relapses often occurred when months of medication was discontinued. Nearly monthly symptomatic relapses (>10) were not unusual and resulted in important manpower losses after each campaign.
View Article and Find Full Text PDFOrgan-preserving embolization of a giant splenic hemangioma in an adult.
CVIR Endovasc
November 2024
Interventional Unit of Radiology, Agios Savas Anticancer Hospital, Alexandras Avenue 171, Athens, 11522, Greece.
Article Synopsis
- Splenic hemangioma is a rare benign tumor that can cause life-threatening issues if it ruptures; safe management is crucial due to the spleen's importance in immunity and blood filtration.
- A 51-year-old patient with a large spleen hemangioma was treated successfully with embolization, preserving the spleen and avoiding complications.
- The case report highlights the procedure's safety, symptom relief without surgery, and lower complication rates compared to traditional surgical methods, with a notable 2-year follow-up showing significant size reduction of the hemangioma.
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