In response to a record number of immigrant families arriving in the United States through the southern border, a multidisciplinary team at a tertiary care children's hospital developed an inpatient asylum protocol (IAP) whose goals were to identify, screen, and support hospitalized asylum-seeking patients and their families. Identified patients were provided with specialized social work, case management, and legal support and were longitudinally followed after hospital discharge to ensure successful engagement with community resources. A total of 47 patients were enrolled over 2.5 years. Our patient population demonstrated significant food, housing, and legal needs. Medical complexity was also substantial, with half of our patients requiring both inpatient subspecialty consultations and outpatient follow-up and 13% qualifying for our institution's complex care program. As a result of the IAP, all families received social work support that continued after discharge, 93% of families without legal aid on admission were connected with legal resources, and 96% of our patients without a primary care physician on arrival had established one on discharge. At the time of this review, half of our patients and families had graduated from the program, whereas the rest continued to require monthly follow-up because of ongoing needs. This novel program was successful in evaluating and addressing the needs of newly arrived asylum-seeking patients and their families in the inpatient setting. We hope that our protocol will aid other institutions in adopting similar interventions.
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http://dx.doi.org/10.1542/peds.2024-067987 | DOI Listing |
Ann Surg Oncol
January 2025
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Background: Bilateral risk-reducing mastectomies (RRMs) have been proven to decrease the risk of breast cancer in patients at high risk owing to family history or having pathogenic genetic mutations. However, few resources with consolidated data have detailed the patient experience following surgery. This systematic review features patient-reported outcomes for patients with no breast cancer history in the year after their bilateral RRM.
View Article and Find Full Text PDFEur J Hum Genet
January 2025
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a rare neurodegenerative disorder characterized by spastic paraplegia, parkinsonism and psychiatric and/or behavioral symptoms caused by variants in gene encoding chromosome-19 open reading frame-12 (C19orf12). We present here seven patients from six unrelated families with detailed clinical, radiological, and genetic investigations. Childhood-onset patients predominantly had a spastic ataxic phenotype with optic atrophy, while adult-onset patients were presented with cognitive, behavioral, and parkinsonian symptoms.
View Article and Find Full Text PDFHum Genet
January 2025
Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-Ku, Tokyo, 152-8902, Japan.
There are hundreds of rare syndromic diseases involving hearing loss, many of which are not targeted for clinical genetic testing. We systematically explored the genetic causes of undiagnosed syndromic hearing loss using a combination of whole exome sequencing (WES) and a phenotype similarity search system called PubCaseFinder. Fifty-five families with syndromic hearing loss of unknown cause were analyzed using WES after prescreening of several deafness genes depending on patient clinical features.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating the the current status of chronic obstructive pulmonary disease (COPD) management under the system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers in China were included and analyzed. We assessed the statistical significance of differences by one way analysis of variance (ANOVA) for continuous variables and with the chi-squared test for categorical variables.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Computer Science and Engineering, Shahid Beheshti University, Tehran, Iran.
Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitive impairment between them.
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