AI Article Synopsis

  • The effectiveness of ceftriaxone in determining susceptibility to newer oral cephalosporins is uncertain.
  • In a study of 409 bloodstream isolates of Enterobacterales, ceftriaxone susceptibility correlated with high rates of susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%).
  • When focusing only on isolates that were susceptible to ceftriaxone, the susceptibility rates for the four oral cephalosporins increased to between 92% and 99%.

Article Abstract

The reliability of ceftriaxone for inferring susceptibility to higher-generation oral cephalosporins is unknown. Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to , isolates susceptible to ceftriaxone.

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http://dx.doi.org/10.1128/aac.01387-24DOI Listing

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Article Synopsis
  • The effectiveness of ceftriaxone in determining susceptibility to newer oral cephalosporins is uncertain.
  • In a study of 409 bloodstream isolates of Enterobacterales, ceftriaxone susceptibility correlated with high rates of susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%).
  • When focusing only on isolates that were susceptible to ceftriaxone, the susceptibility rates for the four oral cephalosporins increased to between 92% and 99%.
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