Borenium ions have attracted significant attention in organic transformations due to their strong Lewis acidity. The reported borenium ions are often stabilized by sterically demanding substituents and strong coordination bonds. Herein, we have synthesized a small steric borenium-equivalent NHBHOTf and subjected it to the exhaustive reduction of a carboxylic functional group to a methyl group, which shows broad functional group tolerance. This system can also undergo a reductive deoxygenation reaction of alcohols, ethers, and other oxo-chemicals (100 examples). The mechanistic studies revealed that the -generated NHBHOTf/[NHBH(sol)]OTf, rendering the borenium-like properties, plays a crucial role in these transformations by interacting with the O atom of substrates to activate the carbonyl group and facilitating the cleavage of the C-O bond. This work has not only offered a system for the exhaustive reduction of oxo-chemicals but is also of great significance for providing insight into the application of the borenium ions in various reactions.
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PLoS One
January 2025
Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
The identification of immune environments and cellular interactions in the colon microenvironment is essential for understanding the mechanisms of chronic inflammatory disease. Despite occurring in the same organ, there is a significant gap in understanding the pathophysiology of ulcerative colitis (UC) and colorectal cancer (CRC). Our study aims to address the distinct immunopathological response of UC and CRC.
View Article and Find Full Text PDFDalton Trans
January 2025
College of Life Sciences, School of Chemical Engineering, Key Laboratory of Green Catalysis of Jiangxi Education Institutes, Jiangxi Normal University, Nanchang 330022, China.
The photocatalytic conversion of CO and HO into useful chemicals or fuels over semiconductor photocatalysts is regarded as a promising technology to address the problems of global warming and energy exhaustion. However, inefficient photo-absorption and slow charge dynamics limit the CO photoreduction efficiency. Here, a ternary heterojunction photocatalyst, CuCl(OH)/In/InO (Cu H IO), with an intimate interface is obtained a hydrogen chemical reduction approach followed by hydrolysis reaction, where In species can be produced on the surface of InO from the hydrogen chemical reaction with a calcining temperature of over 500 °C.
View Article and Find Full Text PDFDevelopment
January 2025
Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.
To maintain and regenerate adult tissues after injury, division and differentiation of tissue-resident stem cells must be precisely regulated. It remains elusive which regulatory strategies prevent exhaustion or overgrowth of the stem cell pool, whether there is coordination between multiple mechanisms, and how to detect them from snapshots. In Drosophila testes, somatic stem cells transition to a state that licenses them to differentiate, but remain capable of returning to the niche and resuming cell division.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
School of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Materials, Henan Normal University, Xinxiang, Henan453007,China.
Borenium ions have attracted significant attention in organic transformations due to their strong Lewis acidity. The reported borenium ions are often stabilized by sterically demanding substituents and strong coordination bonds. Herein, we have synthesized a small steric borenium-equivalent NHBHOTf and subjected it to the exhaustive reduction of a carboxylic functional group to a methyl group, which shows broad functional group tolerance.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute, Bhubaneswar-752050, India.
The reduction of aryl carboxylates to methyl and allyl arene was attained using a well-defined cobalt catalyst. This catalytic transformation employs only a sub-stoichiometric amount of base, and diethylsilane as a reductant. Catalytic activation of the Si-H bond of the silanes, C-O bond of the ester, and silyl ether intermediates by cobalt is crucial to achieving exhaustive reduction.
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