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Right ventricular function in athletes engaged in endurance exercise using speckle tracking echocardiography: a meta-analysis.
BMC Cardiovasc Disord
January 2025
Department of Ultrasonography, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Background: Long-term endurance training is associated with structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes. Many studies have focused on structural changes in the right ventricle (RV) and few have examined functional adaptation of the right ventricle. This meta-analysis aims to compare the changes in right ventricular systolic function between endurance athletes and controls before and after exercise using speckle tracking echocardiography (STE).
View Article and Find Full Text PDFDeep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS.
BMC Immunol
January 2025
Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, Conservatoire National des Arts et Métiers, 2 rue Conté 75003, Paris, EA7528, France.
Introduction: We have reanalyzed the genomic data from the International Collaboration for the Genomics of HIV (ICGH), focusing on HIV-1 Elite Controllers (EC).
Methods: A genome-wide association study (GWAS) was performed, comparing 543 HIV-1 EC individuals with 3,272 uninfected controls (CTR) of European ancestry. 8 million single nucleotide polymorphisms (SNPs) and HLA class I and class II gene alleles were imputed to compare EC and CTR.
Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs.
Exp Mol Med
January 2025
Department of Physiology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Hemophilia A (HA) is caused by mutations in coagulation factor VIII (FVIII). Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic mutations with normal proteins. However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA.
View Article and Find Full Text PDFFollow-up care needs and motivational factors for childhood cancer survivors and their parents in Germany.
Sci Rep
January 2025
Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.
This study aims to explore the long-term follow-up needs and motivations of childhood and adolescent cancer survivors and their parents to attend follow-up care in Germany, given the inconsistent adherence to national follow-up guidelines. We developed interview guidelines based on the Theory of Planned Behavior and the stereotype priming model to explore motivations and barriers related to follow-up care. We conducted a total of 36 episodic narrative interviews with adolescent (ages 13-17) and adult (ages 18-45) survivors of pediatric cancer, as well as their parents.
View Article and Find Full Text PDFGrowing old before growing rich: a scoping review on ageing-related policy interventions from the WHO Southeast Asian Region.
BMJ Open
January 2025
Department of Social and Health Innovation, Prasanna School of Public Health, Manipal, Karnataka, India.
Background: WHO Southeast Asian Region (WHO SEARO) is home to 1.94 billion people accounting for one-fourth of the global population.
Objective: The primary objective of this scoping review is to describe the various policy interventions implemented in countries of the WHO SEARO to address the consequences of ageing.
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