AI Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease affecting young adults, where the immune system attacks the protective myelin sheath of nerve cells, leading to neurological symptoms.
- The study aims to analyze the glycosylation profiles of immunoglobulin G (IgG) in suspected MS patients through advanced techniques like MALDI-TOF mass spectrometry to identify differences in glycan patterns associated with varying oligoclonal band types.
- Findings indicate that changes in IgG glycosylation may act as potential biomarkers for MS, aiding in understanding the disease's mechanisms and improving diagnostic methods.
Article Abstract
Multiple sclerosis (MS) is a common autoimmune disease that primarily affects young adults. In this condition, the immune system attacks the myelin sheath of nerve cells, leading to a variety of neurological symptoms. MS diagnosis often relies on the analysis of oligoclonal bands (OCBs), which involves detecting oligoclonal immunoglobulin G (IgG) bands in cerebrospinal fluid (CSF) and serum. The objective of this study was to investigate the glycosylation profiles of IgG in patients suspected of having MS, using glycan analysis with MALDI-TOF mass spectrometry. Serum samples were analysed, and the IgG glycosylation patterns were compared across different OCB types. Our findings suggest that alterations in IgG glycans may serve as potential biomarkers for MS, providing insights into the disease's molecular mechanisms and aiding in early diagnosis. This study highlights the importance of glycomics in understanding the pathogenesis of MS and in the development of novel diagnostic techniques.
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| http://dx.doi.org/10.1039/d4ay01639d | DOI Listing |
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