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Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment. | LitMetric

AI Article Synopsis

  • Osteoarthritis (OA) is a prevalent joint disorder that leads to cartilage breakdown, causing significant pain and potential deformities, with current treatment options showing limitations.
  • Cartilage organoids, which mimic natural cartilage structures, can help advance OA research and serve as effective fillers for cartilage repair due to their three-dimensional properties and structure.
  • Silk fibroin (SF)-based hydrogels are highlighted as ideal materials for creating these organoids, providing excellent mechanical properties and biocompatibility, and their development is enhanced through artificial intelligence for optimized treatment solutions.

Article Abstract

Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration. It can cause severe pain, deformity and even amputation risk. However, existing clinical treatment methods for cartilage repair present certain deficiencies. Meanwhile, the repair effect of cartilage tissue engineering is also unsatisfactory. Cartilage organoids are multicellular aggregates with cartilage-like three-dimensional structure and function. On the one hand, cartilage organoids can be used to explore the pathogenesis of OA by constructing disease models. On the other hand, it can be used as filler for rapid cartilage repair. Extracellular matrix (ECM)-like three-dimensional environment is the key to construct cartilage organoids. Silk fibroin (SF)-based hydrogels not only have ECM-like structure, but also have unique mechanical properties and remarkable biocompatibility. Therefore, SF-based hydrogels are considered as ideal biomaterials for constructing cartilage organoids. In this review, we reviewed the studies of cartilage organoids and SF-based hydrogels. The advantages of SF-based hydrogels in constructing cartilage organoids and the iterative optimization of cartilage organoids through designing hydrogels by using artificial intelligence (AI) calculation are also discussed. This review aims to provide a theoretical basis for the treatment of OA using SF-based biomaterials and cartilage organoids.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671376PMC
http://dx.doi.org/10.7150/thno.103491DOI Listing

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