[This retracts the article DOI: 10.3389/fnmol.2017.00208.].
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Retraction: Endothelial-monocyte activating polypeptide II suppresses the glioblastoma-induced angiogenesis by inducing autophagy.
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[This retracts the article DOI: 10.3389/fnmol.2017.
View Article and Find Full Text PDFEndothelial-Monocyte Activating Polypeptide II Suppresses the Glioblastoma-Induced Angiogenesis by Inducing Autophagy.
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June 2017
Department of Neurobiology, College of Basic Medicine, China Medical UniversityShenyang, China.
The obstacle in delivering therapeutics to glioblastoma (GBM) is tumor-induced angiogenesis which leads to the formation of abnormal vessels and a dysfunctional blood-tumor barrier. Here, we elucidated the effect of endothelial-monocyte activating polypeptide II (EMAP II) on the GBM-induced angiogenesis as well as its potential mechanisms. Our results proved that EMAP II inhibited the viability, mitochondrial membrane potential, migration and tube formation of GBM-induced endothelial cells (GECs) by inducing cell autophagy, demonstrated by cell viability assay, JC-1 staining assay, transwell assay and tube formation assay, respectively.
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