AI Article Synopsis
- Genetic variations in the interleukin-13 gene may influence asthma risk across different ethnic groups, and this study focused on two specific genetic polymorphisms in Sudanese patients.
- A case-control study involved 50 asthmatic patients and 50 control individuals, using a specialized genetic testing method to analyze the polymorphisms.
- Results indicated that the rs1800925 polymorphism is significantly linked to increased asthma susceptibility, while the rs20541 polymorphism showed no association with the condition.
Article Abstract
Genetic polymorphisms in interleukin-13 () gene have been associated with asthma susceptibility in different ethnicities. We investigated the association of two polymorphisms in the gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients. A case-control study was conducted at Al-Shaab Teaching Hospital between April and October 2022. Involving fifty asthmatic patients and fifty controls. The genotypes were determined using an allele-specific polymerase chain reaction. For rs1800925, a significant association with asthma in multivariate analysis (aOR=3.15, 95% CI: 1.13-8.76; p=0.028). The T allele was the most frequent in cases and showed a significant association with asthma (aOR=1.99, 95% CI: 1.13-3.5; p=0.016). The rs20541 did not show any association with asthma. The rs1800925 is associated with an increased risk of asthma in Sudanese patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624611 | PMC |
| http://dx.doi.org/10.22099/mbrc.2024.50865.2017 | DOI Listing |
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