Despite extensive research, determining the optimal level of sunlight exposure for human health remains a challenge, emphasizing the need for ongoing scientific inquiry into this critical aspect of human well-being. This review aims to elucidate how different components of the solar spectrum, particularly near-infrared (NIR) radiation and ultraviolet radiation (UVR) affect human health in diverse ways depending on factors such as time of day and duration of exposure. Sunlight has beneficial effects from the production of melatonin by NIR and vitamin D by UVB. Sunlight also causes harmful effects as evidenced by oxidative stress and DNA damage. Exposure to morning and evening sunlight when the UV index is below 3 is suggested to be beneficial for harnessing its positive effects while avoiding the harmful effects of UVR when the UV index is 3 or higher. Understanding the optimal timing and duration of sunlight exposure is crucial for harnessing its beneficial effects while minimizing its harmful consequences by adopting appropriate sun protection measures. By adhering to sun protection guidelines when the UV index is 3 or more and incorporating strategic exposure to NIR rays when the UV index is less than 3, individuals can optimize their health outcomes while mitigating the risks associated with sun exposure. Given that the effects of sun exposure can be both harmful and beneficial, and Australia's unique geographical position where it experiences the highest levels of exposure to sunlight, it is vital to understand the appropriate level and timing of sun exposure to live healthy under the Australian sun.
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http://dx.doi.org/10.3389/fpubh.2024.1505904 | DOI Listing |
Sci China Life Sci
December 2024
Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital, Frontier Science Center for Stem Cells, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Inflammation is a driving force of hematopoietic stem cells (HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs.
View Article and Find Full Text PDFActa Pharmacol Sin
January 2025
National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Sorting nexins (SNXs) as the key regulators of sorting cargo proteins are involved in diverse diseases. SNXs can form the specific reverse vesicle transport complex (SNXs-retromer) with vacuolar protein sortings (VPSs) to sort and modulate recovery and degradation of cargo proteins. Our previous study has shown that SNX3-retromer promotes both STAT3 activation and nuclear translocation in cardiomyocytes, suggesting that SNX3 might be a critical regulator in the heart.
View Article and Find Full Text PDFSci Rep
January 2025
Univ. Grenoble Alpes, CEA, CNRS, Grenoble INP, SyMMES, Grenoble, F-38000, SyMMES, France.
Pigment particles used in tattooing may exert long terms effect by releasing diffusible degradation products. In the present work, aqueous suspensions of the organic orange diazo pigment PO13 were aged by exposure to simulated sunlight at 40 °C. The morphology and the surface charge of PO13 particles were barely modified upon aging, but primary particles were released by de-agglomeration.
View Article and Find Full Text PDFSci Rep
January 2025
Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, La Laguna, Spain.
This study investigated how exposure to Caucasian and Chinese faces influences native Mandarin-Chinese speakers' learning of emotional meanings for English L2 words. Participants were presented with English pseudowords repeatedly paired with either Caucasian faces or Chinese faces showing emotions of disgust, sadness, or neutrality as a control baseline. Participants' learning was evaluated through both within-modality (i.
View Article and Find Full Text PDFJ Neurosci
January 2025
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular Biology, Miami, FL 33136.
The opioid epidemic endangers not only public health but also social and economic welfare. Growing clinical evidence indicates that chronic use of prescription opioids may contribute to an elevated risk of ischemic stroke and negatively impact post-stroke recovery. In addition, NLRP3 inflammasome activation has been related to several cerebrovascular diseases, including ischemic stroke.
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