Alanine aminotransferase (AlaAT) is a crucial enzyme present in various isoforms. It is playing vital role in both humans and plants. This concise review focuses on the role of AlaAT in plants, particularly on preharvest sprouting, hypoxia, nitrogen use efficiency, abiotic and biotic stress tolerance. The molecular genetics of AlaAT, including gene identification and the impact on plant yield and its physiology, is discussed. Notably, the major dormancy gene governing AlaAT synthesis has been characterized and cloned in various crops. This review emphasizes the current understanding of AlaAT and its influence on plants, covering mechanisms regulating preharvest sprouting, hypoxia, drought tolerance, salt tolerance, biotic resistance and nitrogen use efficiency. Identifying a protein with multidimensional roles in crop plants is very important. Modern biotechnological approaches can alter such candidate gene/protein for superior varieties development. Overall, the review gives an understanding of the uncovered area of AlaAT and the challenge of climatic change triggers in plants. In the future, the potential of genome editing in AlaAT through enhancer insertion and rapid stabilization through speed breeding will impart resilience to crop plants against climate change.
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http://dx.doi.org/10.1007/s12298-024-01540-8 | DOI Listing |
Poult Sci
December 2024
Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.
To enhance the health and performance of poultry, novel approaches have to be created. Using appropriate nutritional interventions to enhance body physiology and thus enhance productivity is one of these approaches. The purpose of the present investigation intended to examine how growing quail physiology and growth is affected by supplementing diets with tryptophan (Trp) and/or canthaxanthin (CX).
View Article and Find Full Text PDFJ Complement Integr Med
January 2025
Department of Basic Medical Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Excessive fluoride exposure leads to increased oxidative stress and lipid peroxidation, causing harmful effects on the metabolic organs in the human body. Betanin, a pigment obtained from beetroot, is seen to have powerful anti-inflammatory and antioxidant. The study was conducted to determine the role of betanin in fluoride induced hepato-renal toxicity in Wistar rats.
View Article and Find Full Text PDFInflammopharmacology
January 2025
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, 63100, Pakistan.
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, gastric disorders, and as an analgesic. Chemo-herbal combinations are known to have potent anti-inflammatory and analgesic effects, while mitigating the drug related side effects.
View Article and Find Full Text PDFWorld J Urol
January 2025
Department of Urology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Propose: This study aimed to evaluate the efficacy and safety of neoadjuvant treatment of darolutamide, a next-generation androgen receptor inhibitor, plus androgen deprivation therapy (ADT) for patients with locally advanced prostate cancer (LAPC).
Methods: This single-arm, multicenter, open-label phase II trial (ClinicalTrials.gov: NCT05249712, 2022-01-01), recruited 30 localized high-risk/very high-risk prostate cancer (HRPCa/VHRPCa) patients from three centers in China between 2021 and 2023.
J Viral Hepat
February 2025
Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
The exclusion of cirrhosis is important in chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT). We aimed to optimise the performance of the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis score based on four factors (FIB-4) to exclude cirrhosis in these patients. Five hundred and eighty four patients with normal ALT who underwent liver biopsy were included in the study.
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