AI Article Synopsis
- Evidence-based screening is essential for detecting myocardial ischemia in high-risk diabetics, particularly by analyzing nitric oxide levels, lipid profiles, and atherogenic indices in those with coronary artery disease (CAD).
- A study involved 50 diabetics with CAD, 30 without CAD, and 23 healthy individuals, measuring various biochemical parameters and plasma nitric oxide through the Griess reaction.
- Results indicated that diabetics with CAD had elevated levels of nitric oxide and triglycerides, whereas their cholesterol levels were lower, and there was a significant positive correlation between nitric oxide and glycated hemoglobin, highlighting the link between chronic hyperglycemia and potential vascular complications in diabetes.
Article Abstract
Background: Evidence-based screening is crucial to detect myocardial ischemia in high-risk diabetics. We explored the relationship between nitric oxide (NO) levels, lipid profile indices, and atherogenic index of plasma (AIP) in type 2 diabetics with coronary artery disease (CAD) and to determine their potential as prognostic markers.
Materials And Methods: A case-control study included 50 diabetics with CAD (cases), 30 diabetics without CAD (control 1), and 23 healthy controls (control 2). Biochemical parameters were determined using standard protocols; plasma NO was measured via the Griess reaction.
Results: Cases had the highest levels of NO, fasting blood sugar, glycated hemoglobin (HbA1c), and triglycerides, and the lowest total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. Cases exhibited the highest TC: HDL-C, LDL-C: HDL-C, and AIP ratios. A significant positive correlation between NO and HbA1c ( = 0.328, = 0.020).
Conclusion: Chronic hyperglycemia could enhance NO overproduction driven by inducible isoform, suggesting a potential role for chronic hyperglycemia in endothelial dysfunction and vascular complications in diabetes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11691057 | PMC |
| http://dx.doi.org/10.4103/jrms.jrms_686_23 | DOI Listing |
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