AI Article Synopsis
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART) studied children from 6 months to 8 years and found links between specific gene variants and children's body mass index.
- These associations also connected microbiome characteristics tied to obesity with important lipids and amino acids.
- The findings suggest that genetic factors play a role in influencing the microbiome during development and highlight potential biomarkers for childhood obesity and related health issues like insulin resistance and type 2 diabetes.
Article Abstract
Through the analysis of data from children aged 6 months to 8 years enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), significant simultaneous associations were identified between variants in the fragile histidine triad () gene, children's body mass index, microbiome features related to obesity, and key lipids and amino acids. These patterns represent evidence of the genotype influence in shaping the host microbiome in developing stages and new potential biomarkers for childhood obesity, insulin resistance, and type 2 diabetes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685832 | PMC |
| http://dx.doi.org/10.1002/mlf2.12153 | DOI Listing |
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