Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (n = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg body weight/daily at 14-27 days of age by oral-oesophageal route), and 2.5-ALLI. After 3 to 6 weeks, Hct%, SaO RV:TV ratios, and ATR1 expression in the lung, heart, and liver, were evaluated. Weekly productive performance and AS mortality were recorded. Molecular dockings and dynamic simulations predicted that ALLI might inhibit broiler ATR1 in a transitory manner. At 42 days of age, birds in the 2.5-ALLI group exhibited lower Hct% and lower RV:TV values, while ALLI marginally enhanced SaO. ATR1 expression in the 1-ALLI and 2.5-ALLI groups was higher (i.e., restored) in the lungs and heart, respectively, but not in the liver compared with the untreated group. Productive performance remained unaffected by ALLI, and 2.5-ALLI provided a protection of 4.3% against ascites mortality. In conclusion, 2.5-ALLI mitigated PAH/AS traits in the lungs and heart without compromising broiler productive performance. Further studies adjusting ALLI doses and combinations are warranted.
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http://dx.doi.org/10.1080/03079457.2024.2447284 | DOI Listing |
Avian Pathol
January 2025
Department of Animal Husbandry, Autonomous University of Chapingo, Chapingo, State of Mexico 56230, Mexico.
Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (n = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg body weight/daily at 14-27 days of age by oral-oesophageal route), and 2.
View Article and Find Full Text PDFBioorg Chem
November 2024
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address:
Enzyme Microb Technol
August 2024
Department of Chemical and Biological Engineering, Korea University, Seongbuk-gu, Seoul 02841, South Korea. Electronic address:
Thymoquinone, extracted from the black seeds of Nigella sativa, is a natural substance with highly beneficial effects against various human diseases. In this study, we aimed to construct a Saccharomyces cerevisiae strain that, produce thymoquinone from thymol, a relatively inexpensive substrate. To achieve this, cytochrome P450 from Origanum vulgare was expressed in S.
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February 2024
College of Pharmacy, Sunchon National University, Sunchon 57922, Republic of Korea.
A depside derivative, named pericodepside (), along with the known depside proatranorin III (), was isolated from the solid cultivation of an strain that heterologously expresses and that are involved in the biosynthesis of atranorin in a fruticose lichen, . The structure of was determined by 1D and 2D NMR and MS spectroscopic data. The structure of consisted of a depside-pericosine conjugate, with the depside moiety being identical to that found in , suggesting that acted as an intermediate during the formation of through the esterification process.
View Article and Find Full Text PDFEnviron Toxicol
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Department of Physical Therapy, College of Medical and Health Science, Asia University, Taichung City, Taiwan.
The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti-inflammatory and anti-oxidative capacities.
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