There are many species of animals in the marine environment which are potentially dangerous to humans. Cnidarians that are responsible for burns are mainly found in tropical waters, but there are several species with cosmopolitan distribution. In some cases, contact with toxins from Cnidarians can cause symptoms of acute kidney damage. Because of an enormous diversity of the toxins produced by individual species of cnidaria, the mechanisms of renal damage are different in different cases. Currently, there is only one antitoxin available to treat burns by Cnidarians, this antitoxin can neutralize the toxin produced by Chironex fleckeri. However, recent studies on animal models give hope for the introduction of a universal biological agent that would be capable of inhibiting the activity of toxins produced by a variety of Cnidaria species.
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http://dx.doi.org/10.5603/imh.102878 | DOI Listing |
Alzheimers Dement
December 2024
Yale University School of Medicine, New Haven, CT, USA.
Background: In neurodegenerative disease such as Alzheimer's disease and stroke, the brain transitions to pro-inflammatory profile, where microglia and T-cells in the brain have increase inflammatory profiles, along with increased Kv1.3 potassium channel abundance. Pharmacological blockade of Kv1.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Background: Multiple AD risk genes are implicated in lipid metabolism, and plasma and brain lipid levels are altered in AD. Astrocytes are enriched in key lipid-related factors and are likely contributors to altered lipid homeostasis in AD. We hypothesize that APP/Aβ-related pathology and neuroimmune factors modulate astrocytic gene transcription that promote maladaptive changes in lipid pathways, including aberrant astrocytic production and release of lipids that could affect Aβ pathology and neuronal deficits.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive cognitive decline over age 65. Individuals suffering from this disease suffer memory loss, and histological examination of the brains. Okadaic acid (OA), is a potent and selective inhibitor of protein phosphatases 1 and 2A.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
January 2025
Department of Microbiology, Kogi State University, P.M.B. 1008 Anyigba, Nigeria.
Background: Globally, diarrhoeagenic Escherichia coli (DEC) has been implicated in the spread of waterborne diseases and abattoir wastewater has played a role in its dissemination into watersheds. This study isolated and characterised DEC from the abattoir wastewater-impacted Iyi-Etu River and other water sources at the Amansea livestock market settlement.
Methods: A total of 96 water samples comprising river water (upstream, downstream 1, downstream 2), borehole, well, sachet and abattoir wastewater samples were tested for DEC.
Nat Prod Rep
January 2025
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
Covering: 1960s to 2024Harmful algal blooms pose a major threat to aquatic ecosystems and can impact human health. The frequency and intensity of these blooms has increased over recent decades, driven primarily by climate change and an increase in nutrient runoff. Algal blooms often produce toxins that contaminate water sources, disrupt fisheries, and harm human health.
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