AI Article Synopsis

  • A 63-year-old man experienced vision loss in his left eye and blurred vision in his right eye for four months, initially diagnosed as uveitis by an ophthalmology department.
  • After further evaluation, he was found to have central nervous system lymphoma, leading to systemic treatment, but his vision continued to deteriorate.
  • Eventually, tests revealed intraocular lymphoma in both eyes, and he received eight intravitreal methotrexate injections, resulting in significant improvement in his visual acuity.

Article Abstract

A 63-year-old male patient presented with a four-month history of vision loss in the left eye and blurred vision in the right eye, the cause of which was not immediately apparent. The patient was initially diagnosed with uveitis in both eyes at the Department of Ophthalmology. Subsequently, the patient was diagnosed as central nervous system lymphoma at the Department of Brain Medicine and initiated a systemic treatment. However, due to the progressive deterioration of visual function, a further evaluation was performed at the Department of Ophthalmology. Based on the results of the vitreous fluid cytokine test, intraocular lymphoma was diagnosed in both eyes. Intravitreal methotrexate injections were administered for eight times and a notable improvement in visual acuity was achieved in both eyes.

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http://dx.doi.org/10.3760/cma.j.cn112142-20240308-00102DOI Listing

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Article Synopsis
  • A 63-year-old man experienced vision loss in his left eye and blurred vision in his right eye for four months, initially diagnosed as uveitis by an ophthalmology department.
  • After further evaluation, he was found to have central nervous system lymphoma, leading to systemic treatment, but his vision continued to deteriorate.
  • Eventually, tests revealed intraocular lymphoma in both eyes, and he received eight intravitreal methotrexate injections, resulting in significant improvement in his visual acuity.
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Ocular involvement of lymphoma may present as a primary orbital or intraocular lymphoma or as a manifestation of metastatic disease. Involvement of various ocular structures may be difficult to diagnose due to its rarity and nonspecific clinical presentation. Primary high-grade B-cell lymphoma with MYC and BCL2 rearrangements of the orbit has rarely been reported in the adult population and has not previously been reported in the pediatric population.

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