A catalyst-free photochemical N-acylation of azoles with aldehydes has been developed using inexpensive BrCCl3 as the oxidant. This transition-metal- and photocatalyst-free amidation proceeded efficiently with a wide variety of substrates to give the corresponding N-acylazoles, including for the late modification of pharmaceutically active molecules, and on a gram-scale.
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| http://dx.doi.org/10.1002/chem.202404225 | DOI Listing |
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