[Correlation of Mutation with Clinical Features and Prognosis of Langerhans Cell Histiocytosis in Cildren].

Objective: To explore the gene mutations of Langerhans cell histiocytosis in children, and to analyze the correlation of mutation with clinical features and prognosis of LCH, so as to provide reference for clinical diagnosis and treatment.

Methods: Fluorescence PCR was used to detect gene mutations in paraffin-embedded tissue samples from 78 children with LCH, and the correlation of mutation with clinical characteristics and prognosis of LCH in children was analyzed.

Results: Among the 78 children, 41 cases (52.6 %) had mutation, 8 cases (10.3 %) had mutation, 1 case (1.3 %) had mutation, 1 case (1.3 %) had mutation, and 1 case (1.3%) had mutation. mutation was not significantly correlated with sex, age, multisystem involvement, risk-organ involvement, CNS-risk lesions, and early treatment response in children with LCH ( >0.05), and it was also not significantly correlated with the recurrence and event-free survival (EFS) of children with LCH ( >0.05).

Conclusion: LCH is an inflammatory myeloid tumor. mutation is not correlated with clinical features, early treatment response, recurrence and prognosis of LCH.