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Imputation for Lipidomics and Metabolomics (ImpLiMet): a web-based application for optimization and method selection for missing data imputation.
Bioinform Adv
January 2025
Digital Technologies Research Centre, National Research Council of Canada, Ottawa, ON K1K 4P7, Canada.
Motivation: Missing values are prevalent in high-throughput measurements due to various experimental or analytical reasons. Imputation, the process of replacing missing values in a dataset with estimated values, plays an important role in multivariate and machine learning analyses. The three missingness patterns, including missing completely at random, missing at random, and missing not at random, describe unique dependencies between the missing and observed data.
View Article and Find Full Text PDFDevelopment and implementation of a digiphysical screening model with nationwide reach to diagnose familial hypercholesterolemia.
Digit Health
January 2025
Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Background: Familial hypercholesterolemia (FH) is a hereditary dyslipidemia that confers a severely elevated risk for development of early atherosclerotic cardiovascular disease if left untreated. FH is underdiagnosed in most countries including Sweden.
Aim: To develop and evaluate the implementation of a digiphysical screening model to diagnose FH in the clinical routine.
Overview of basic design recommendations for user-centered explanation interfaces for AI-based clinical decision support systems: A scoping review.
Digit Health
January 2025
Institute for Medical Informatics and Biometry, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Objective: The application of artificial intelligence (AI)-based clinical decision support systems (CDSS) in the healthcare domain is still limited. End-users' difficulty understanding how the outputs of opaque black AI models are generated contributes to this. It is still unknown which explanations are best presented to end users and how to design the interfaces they are presented in (explanation user interface, XUI).
View Article and Find Full Text PDFEmpowerment in structures. Practical-ethical considerations of the preconditions for technology-assisted dementia care in Germany based on an expert-interview study.
Front Psychiatry
January 2025
Department of Medical Ethics and History of Medicine, University Medical Center Göttingen, Göttingen, Germany.
Background: Intelligent assistive technologies (IAT) have become more common in dementia care. Ethical reflection on technology-assisted dementia care (TADC) has focused so far mainly on individual and interpersonal implications (e.g.
View Article and Find Full Text PDFA mixed-methods investigation of a digital mental health tool to manage posttrauma anger.
J Trauma Stress
January 2025
Phoenix Australia-Centre for Posttraumatic Mental Health, Department of Psychiatry, University of Melbourne, Carlton, Victoria, Australia.
Problematic anger affects up to 30% of individuals who have experienced trauma. Digital mental health approaches, such as ecological momentary assessment (EMA) delivered via smartphone and wearable devices (i.e.
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