AI Article Synopsis
- Acarbose plays a significant role in reducing inflammation related to obesity and insulin resistance by influencing adipose tissue macrophages (ATMs).
- Acarbose promotes the growth of beneficial gut bacteria that produce propionic acid, which helps inhibit the proinflammatory M1-like ATMs.
- The study shows that acarbose directly targets and inhibits these inflammatory macrophages, suggesting its potential for therapeutic use in managing obesity and insulin resistance.
Article Abstract
Inflammation is critical for obesity and obesity-induced insulin resistance (IR). In this study, we reveal the function and mechanism of acarbose on adipose tissue macrophage (ATM)-mediated inflammation in obesity and obesity-induced IR. First, acarbose enhances the abundance of propionic acid-producing Parasutterella, therefore indirectly inhibiting the survival and proinflammatory function of M1-like ATMs via GPR43. Most interestingly, acarbose can directly inhibit M1-like ATM-mediated inflammation through GPR120. Diet-induced obese mice exhibit nitrobenzoxadiazoles (NBD) fluorescence-labeled ATMs, but lean mice that also orally received NBD fluorescence-labeled acarbose do not exhibit NBD fluorescence-labeled ATMs. This direct inhibition of macrophages by acarbose is validated in mouse and human macrophages in vitro. In conclusion, our study reveals that acarbose directly and indirectly inhibits proinflammatory macrophage phenotype, which contributes to the improvement of obesity and obesity-induced IR. The understanding of the immune regulatory effects of acarbose may extend its potential for further therapeutic applications.
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| http://dx.doi.org/10.1016/j.xcrm.2024.101883 | DOI Listing |
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Article Synopsis
- Acarbose plays a significant role in reducing inflammation related to obesity and insulin resistance by influencing adipose tissue macrophages (ATMs).
- Acarbose promotes the growth of beneficial gut bacteria that produce propionic acid, which helps inhibit the proinflammatory M1-like ATMs.
- The study shows that acarbose directly targets and inhibits these inflammatory macrophages, suggesting its potential for therapeutic use in managing obesity and insulin resistance.
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