The Covid-19 pandemic uncovered several lacunae in healthcare systems exposing global unpreparedness and triggering unprecedented challenges worldwide- necessitating a shift towards mitigation and robust surveillance strategies. Here, we report the use of Whole Genome Sequencing (WGS) to detect SARS-CoV-2 variants in clinical samples of Meghalaya, India, using Oxford Nanopore Technology. SARS-CoV-2 positive samples collected from various districts of Meghalaya from August 2021 to May 2023 were subjected to WGS. Out of a total of 965 samples, Alpha (0.1 %), Delta (47.2 %) and Omicron (52.7 %) variants were detected. The Delta variant affected 53 % of individuals under the age of 18 years, while the Omicron sub variant BA.2 affected all age groups in a similar manner. The study underscores the efficacy of using a user-friendly sequencing device coupled with simplified bioinformatics, enabling remote regions to effectively combat Covid-19. This approach, characterized by rapidity, simplicity and accuracy, holds promise in confronting future health crises.
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http://dx.doi.org/10.1016/j.diagmicrobio.2024.116670 | DOI Listing |
Sci Rep
January 2025
Division of Microbiology, Indian Agricultural Research Institute, New Delhi, 110012, India.
Root-knot nematodes (Meloidogyne spp.) are significant pests that cause considerable damage to crops, prompting a need for sustainable control methods. This study evaluated the nematicidal potential of fungal culture filtrates and botanicals as eco-friendly alternatives.
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January 2025
Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati, Assam, 781035, India.
Medicinal plants often harbour various endophytic actinomycetia, which are well known for their potent antimicrobial properties and plant growth-promoting traits. In this study, we isolated an endophytic actinomycetia, A13, from the leaves of tea clone P312 from the MEG Tea Estate, Meghalaya, India. The isolate A13 was identified as Streptomyces sp.
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January 2025
School of Crop Improvement, College of Post Graduate Studies in Agricultural Sciences, CAU (Imphal), Umiam, Meghalaya, India.
Faba bean is a nutritionally and medicinally rich popular legume crop. However, vicine-convicine remain as potential threats for "favism" in human beings. In this study, 189 diverse faba bean accessions have been evaluated for yield component traits and vicine content in seeds followed by a correlation study.
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Department of Pediatrics, Gauhati Medical College & Hospital, Guwahati, Assam, 781032, India.
Diagn Microbiol Infect Dis
December 2024
Pasteur Institute, Directorate of Health Services (Research etc.), Lawmali, Shillong 793001, Meghalaya, India.
The Covid-19 pandemic uncovered several lacunae in healthcare systems exposing global unpreparedness and triggering unprecedented challenges worldwide- necessitating a shift towards mitigation and robust surveillance strategies. Here, we report the use of Whole Genome Sequencing (WGS) to detect SARS-CoV-2 variants in clinical samples of Meghalaya, India, using Oxford Nanopore Technology. SARS-CoV-2 positive samples collected from various districts of Meghalaya from August 2021 to May 2023 were subjected to WGS.
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