AI Article Synopsis
- A new palladium-catalyzed method has been developed to synthesize three natural products: (-)-lyngbyatoxin, (-)-teleocidin A2, and (-)-7-geranylindolactam V, using a technique called the Suzuki-Miyaura reaction.
- This approach utilizes a ligand-controlled cross-coupling strategy, making it possible to create these compounds from a single advanced synthetic intermediate, which is the most efficient method reported to date.
- Following the synthesis, research was conducted on cancer cell lines to investigate the potential cancer-fighting properties of these natural products.
Article Abstract
A regiodivergent palladium-catalyzed Suzuki-Miyaura reaction has been successfully implemented to synthesize (-)-lyngbyatoxin, (-)-teleocidin A2, and (-)-7-geranylindolactam V. This ligand-controlled cross-coupling strategy allowed for the direct preparation of these natural products from a single advanced synthetic intermediate, providing the shortest reported route to each compound. Subsequent studies in cancer cell lines were conducted to explore the chemotherapeutic applications of these natural products.
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| http://dx.doi.org/10.1021/acs.joc.4c02877 | DOI Listing |
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