Extramedullary plasmacytoma of the parotid gland is an extremely rare lesion of which there have been only four other reported cases. The importance of these lesions rests in the possibility of their being a harbinger of multiple myeloma or their subsequent transformation to multiple myeloma. Because of its extreme rarity, the proper management remains unclear.
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Rapidly Enlarging Parotid Mass in a Person Living with HIV: A Case of Multiple Myeloma with Extramedullary Plasmacytoma.
Am J Case Rep
August 2023
Division of Infectious Disease, Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
BACKGROUND The differential diagnosis for a parotid mass is broad, including infectious, autoimmune, and neoplastic etiologies. In people with HIV, regardless of viral suppression or immune status, neoplastic causes are more common. This report describes the evaluation of a woman with a large parotid mass, with an ultimate diagnosis of multiple myeloma with extramedullary plasmacytoma.
View Article and Find Full Text PDFA case report of multiple extramedullary plasmacytoma of the head and neck.
Medicine (Baltimore)
December 2022
Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Rationale: Multiple extramedullary plasmacytoma (EMP) of the head and neck is rare and a definitive first-line treatment has not been established. EMP successively as a benign mass occurring in multiple areas of the head and neck is rare. This report describes an atypical case with EMP occurring in multiple areas of the head and neck.
View Article and Find Full Text PDFBilateral Orbital Plasmacytomas With Orbital Compartment Syndrome.
Cureus
June 2022
Department of Hematology and Oncology, Banner MD Anderson Cancer Center, Phoenix, USA.
Orbital plasmacytomas are uncommon soft-tissue plasma cell neoplasms that are associated with a monoclonal or myeloma protein. There are four types of plasma cell neoplasms: multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), amyloidosis, and plasmacytoma. Plasmacytomas may be classified as medullary, occurring only within the bone, or extramedullary, occurring in soft tissues.
View Article and Find Full Text PDFParotid gland swelling as an initial presentation of Multiple Myeloma: a case report.
Cardiovasc Hematol Disord Drug Targets
May 2022
Professor and Medical Superintendent, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Introduction: Parotid swellings are commonly encountered in ENT Clinics, the cause of which could range from neural conditions, endocrine problems, vitamin deficiencies, and sialadenitis, which may even be a manifestation of an underlying systemic disease. Multiple myeloma represents a clonal proliferation of plasma cells and is a condition in which a parotid swelling might be present, although very uncommon.
Case Presentation: We report a case of 60-year-old female presented with unilateral parotid swelling, which led to a diagnosis of multiple myeloma based on the investigations.
Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease.
J Oral Maxillofac Pathol
March 2021
Department of Oral and Maxillofacial Surgery, General Hospital George Papanikolaou, Thessaloniki, Greece.
Solitary extramedullary plasmacytomas of the head and neck region are rare entities. Very few have been described in the parotid gland. They can clinically and radiologically mimic the rather common benign tumors of the parotid gland (pleomorphic adenoma and Wharthin's tumor), and subsequently the need careful consideration by the involving surgeon and pathologist is needed for a proper diagnosis.
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