AI Article Synopsis
- O-GlcNAcylation is a modification that adds a sugar molecule, N-acetylglucosamine, to specific amino acids, influencing signaling pathways important for pyroptosis, a form of cell death.
- Enhancing O-GlcNAcylation of the protein GSDMD is suggested as a key strategy for improving blood flow issues in sepsis, while GSDME's role in macrophage pyroptosis is linked to high glucose levels in periodontitis.
- The review discusses O-GlcNAcylation's impact on the NLRP3 inflammasome and other regulators, highlighting its potential as a therapeutic target for diseases like sepsis and osteoarthritis by managing inflammation.
Article Abstract
O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of pyroptosis, suggesting that enhancing O-GlcNAcylation of GSDMD could be crucial for improving hypoperfusion in sepsis. Additionally, GSDME, another member of the gasdermin family, facilitates macrophage pyroptosis through O-GlcNAcylation induced by high glucose levels in the context of periodontitis. The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-κB. Overall, this review emphasizes the role of O-GlcNAcylation in the pathogenesis of conditions such as sepsis, periodontitis, and osteoarthritis, identifying potential therapeutic targets for managing inflammatory responses through its targeted modulation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685218 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1513542 | DOI Listing |
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