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| http://dx.doi.org/10.3389/fimmu.2024.1537054 | DOI Listing |
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Editorial: Single-domain antibodies-biology, engineering and emerging applications, volume II.
Front Immunol
December 2024
Department of Chemistry and Biochemistry, California State University Fresno, Fresno, CA, United States.
ImmunoPET imaging of EpCAM in solid tumours with nanobody tracers: a preclinical study.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Purpose: Epithelial cell adhesion molecule (EpCAM) is a potential therapeutic target and anchoring molecule for circulating and disseminated tumour cells (CTC/DTC) in liquid biopsy. In this study, we aimed to construct EpCAM-specific immuno-positron emission tomography (immunoPET) imaging probes and assess the diagnostic abilities in preclinical cancer models.
Methods: By engineering six single-domain antibodies (e.
Trimeric Bet v 1-specific nanobodies cause strong suppression of IgE binding.
Front Immunol
May 2024
Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Background: Around 20% of the population in Northern and Central Europe is affected by birch pollen allergy, with the major birch pollen allergen Bet v 1 as the main elicitor of allergic reactions. Together with its cross-reactive allergens from related trees and foods, Bet v 1 causes an impaired quality of life. Hence, new treatment strategies were elaborated, demonstrating the effectiveness of blocking IgG antibodies on Bet v 1-induced IgE-mediated reactions.
View Article and Find Full Text PDFAntibody fragments can act as pharmacological tools to modulate the functions of G protein-coupled receptors.
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