AI Article Synopsis

  • A 67-year-old African American male, diagnosed with "schizophrenia, unspecified," was referred to psychiatry due to auditory and visual hallucinations that began two years after starting Norco for chronic back pain.
  • The patient noted that his hallucinations worsened with increased Norco dosage but disappeared when he stopped taking the medication.
  • The case underscores the risk of misdiagnosing opioid-induced hallucinations as schizophrenia and stresses the need for thorough assessments of opioid use in patients with psychiatric symptoms.

Article Abstract

This article presents the case of a 67-year-old African American male patient who was referred to a psychiatry clinic by his Internal Medicine Provider with a diagnosis of "schizophrenia, unspecified." The patient reported the onset of auditory and visual hallucinations (AVHs) two years ago, coinciding with his starting Norco (hydrocodone 5 mg/acetaminophen 325 mg) for chronic back pain. He noted that his AVH worsened when he increased his prescribed Norco dosage (within his prescribed recommended range) and observed that the hallucinations ceased when he discontinued the medication. This case highlights the potential for opioid-induced AVH to be misdiagnosed as schizophrenia while emphasizing the importance of careful evaluation of opioid use in psychiatric assessments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688156PMC
http://dx.doi.org/10.7759/cureus.74915DOI Listing

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Article Synopsis
  • A 67-year-old African American male, diagnosed with "schizophrenia, unspecified," was referred to psychiatry due to auditory and visual hallucinations that began two years after starting Norco for chronic back pain.
  • The patient noted that his hallucinations worsened with increased Norco dosage but disappeared when he stopped taking the medication.
  • The case underscores the risk of misdiagnosing opioid-induced hallucinations as schizophrenia and stresses the need for thorough assessments of opioid use in patients with psychiatric symptoms.
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Identifying risk factors for opioid-induced neurotoxicity in cancer patients receiving oxycodone.

Support Care Cancer

March 2023

Department of Pharmacy, Iwate Medical University Hospital, 2-1-1 Idaidouri, Yahaba-cho, Shiwa-gun, 028-3695, Iwate, Japan.

Purpose: The aim of this study was to determine the frequency of opioid-induced neurotoxicity (OIN) in cancer patients receiving oral controlled-release oxycodone and to define risk factors for OIN.

Methods: This was a single-center, retrospective study of hospitalized adult cancer patients receiving oral controlled-release oxycodone between April 1, 2013, and April, 30, 2020. The onset of OIN within 30 days after oxycodone initiation in the study patients was investigated.

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Opioids are widely used for the treatment of moderate/severe pain in cancer and noncancer patients. In this study, we searched for safety signals for a wide variety of opioid-related adverse events (AEs) in elderly patients by disproportionality analysis using the Japanese Adverse Drug Event Report (JADER) database. Data from the JADER database from April 2004 to May 2018 were obtained from the Pharmaceuticals and Medical Devices Agency website.

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Opioids are strong analgesics widely employed to treat various types of pain. In 2018, an estimated 168 million opioid prescriptions were dispensed in the United States. Opioids carry a number of side effects and up to 80% of patients treated with opioids experience a minimum of one adverse event.

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Opioid-induced neurotoxicity (OIN) is an underdiagnosed yet distressing symptom in palliative care patients receiving opioids. However, there have been only a limited number of studies on OIN. Our aim was to determine the frequency of and risk factors for OIN in patients receiving opioids during inpatient palliative care.

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