AI Article Synopsis
- Malnutrition and low micronutrient levels are common in patients with ulcerative colitis (UC), and this study examined how different vitamin B groups might help improve the condition.
- Experimental colitis was induced in rats, and both high and normal doses of several B vitamins were administered; results showed significant improvements in weight and ulceration measures following treatment.
- While most vitamins showed beneficial anti-inflammatory effects, pyridoxine was less effective in reducing UC symptoms, indicating a need for further research on the clinical implications of these findings.
Article Abstract
Background: Malnutrition and lack of micronutrients are seen in many patients with ulcerative colitis (UC). Considering that vitamins play an important role in preventing or protecting against inflammation at the metabolic, physiological, and pathological levels, this research was aimed to investigate the effect of a number of vitamin B groups in improving UC.
Methods: Experimental colitis was induced by rectal administration of acetic acid (3%) in male Wistar rats, and mega doses of thiamine (20 mg/kg), riboflavin (15 mg/kg), pyridoxine (30 mg/kg), and cyanocobalamin (250 μg/kg) alone or in combination were administered intraperitoneally for 5 days. In another group, normal dose (1/10 of the above-mentioned doses) of four vitamins in combination was administered for 15 days (started 10 days before colitis induction). Colon tissues were weighted and evaluated in terms of macroscopic, microscopic, and biochemical markers.
Results: Normal dose of four vitamins in combination form and mega dose of thiamine caused a significant increase in the body weight of animals. All treatments except for pyridoxine (mega dose) diminished ulceration index, total colitis index, and colon weight compared to the control group. Myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels decreased significantly in all treatment groups.
Conclusions: The anti-inflammatory and anti-ulcerative properties of selected B vitamins improved experimental colitis regardless of the dosage and duration of treatment. Despite its beneficial effect on biochemical markers, pyridoxine had the least effect in reducing the pathological features of colitis. More studies are needed to confirm the effect of these vitamins in the clinical setting of this disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687687 | PMC |
| http://dx.doi.org/10.4103/ijpvm.ijpvm_232_23 | DOI Listing |
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