Developmental networks comprise individuals (i.e., developers) who take an active interest in and concerted action to advance protégé's career. Research demonstrates that the social composition and characteristics of developmental networks change over time as protégés' careers evolve. However, little qualitative research explores if, how, and why developmental networks change. This analysis examines why protégés change or maintain connections to their developers, focusing on social constraints and deliberative actions. Using an exploratory qualitative approach, we explored the reasons that university faculty respondents changed their developmental networks over time. We considered the potential for individual/developer characteristics and structural constraints on relations between developers and protégés (e.g., job change) to understand how and why respondents added, maintained, or dropped developers from their networks. We conducted 56 semi-structured interviews with faculty mentors and mentees from three universities and the Mountain West Clinical and Translational Research Infrastructure Network, enrolled in a larger study of mentor training interventions. Respondents discussed how their developmental networks changed over 30 months. Self-reported network maps at baseline, 12, and 24 months were used to augment these interviews by showing who was in their network at these time points. Decisions about stability or change in networks mainly appeared unrelated to strategic decisions based on respondents' goals or identified network gaps. Instead, themes related to consistency or change included personal reasons (e.g., position change by respondent), or the personal or situational characteristics of the developer such as: being supportive and trustworthy; a collaborator on projects; genuinely caring; having similar experiences, goals, or values as respondent; social and work overlap; and time or capacity changes (e.g., developer retiring). Our findings establish the rationale for developing and implementing a structured, evidence-based networking intervention to educate faculty on intentionally changing developmental networks based on action plans.
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Genome Biol
January 2025
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 90095, CA, USA.
Deciphering the link between tissue architecture and function requires methods to identify and interpret patterns in spatial arrangement of cells. We present SMORE, an approach to detect patterns in sequential arrangements of cells and examine their associated gene expression specializations. Applied to retina, brain, and embryonic tissue maps, SMORE identifies novel spatial motifs, including one that offers a new mechanism of action for type 1b bipolar cells.
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January 2025
Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.
Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How insult to the cardiac conduction system causes arrhythmias following MI is poorly understood. Here, we demonstrate conduction system restoration during neonatal mouse heart regeneration versus pathological remodeling at non-regenerative stages.
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January 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
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December 2024
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China; Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China. Electronic address:
Background: The long-term impact of childhood maltreatment (CM) on an individual's physical and mental health is suggested to be mediated by altered neurodevelopment. However, the exact neurobiological consequences of CM remain unclear.
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Poult Sci
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College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China; Key Laboratory of Exploration and Innovative Utilization of White Goose Germplasm Resources in the Cold Region of Heilongjiang Province, Daqing 163319, China.
This study aimed to investigate the effects of dietary metabolizable energy levels on various performance indicators of medium-sized geese, with the goal of predicting the optimal range of these energy levels. A comprehensive literature search was conducted across several databases, including Chinese National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, PubMed, Web of Science, and ScienceDirect, covering the period from January 1, 2000, to July 1, 2024. The gathered studies focused on the impact of dietary metabolizable energy levels on the production performance of medium-sized geese.
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