A case report: Endobronchial ultrasound guided biopsy of radiographically normal size thoracic lymph nodes supporting diagnosis of cardiac sarcoidosis.

Respir Med Case Rep

Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.

Published: November 2024

AI Article Synopsis

  • Sarcoidosis is a rare chronic disease with an unclear cause, making cardiac sarcoidosis (CS) diagnosis particularly challenging.
  • Current guidelines for diagnosing CS lack clinical validation, and while endomyocardial biopsy is specific, it is not very sensitive and has significant risks.
  • A case study of a 63-year-old man diagnosed with CS through endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) of normal lymph nodes suggests that EBUS TBNA could be a viable option for diagnosing CS in cases without clear pulmonary sarcoidosis evidence.

Article Abstract

Sarcoidosis is a rare chronic granulomatous disease with unknown etiology. Definite diagnosis of cardiac sarcoidosis (CS) is especially difficult to establish. Several guidelines exist to make a diagnosis of CS but those have not been clinically validated. Despite the high specificity of endomyocardial biopsy, its sensitivity is low, and the severity of potential complications is high. Thus, we present 63-year-old male who was diagnosed with CS with the endobronchial ultrasound (EBUS) transbronchial needle aspiration (TBNA) of intrathoracic lymph nodes which were non-enlarged without PET avidity. EBUS TBNA of radiographically normal appearing lymph nodes showed non-necrotizing granulomas. Given challenges of diagnosing CS, EBUS TBNA can be considered even in cases without obvious evidence of active pulmonary sarcoidosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683332PMC
http://dx.doi.org/10.1016/j.rmcr.2024.102146DOI Listing

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