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Advance Care Planning Billing Codes Associated With Decreased Healthcare Utilization in Neurological Disease.
J Healthc Manag
January 2025
Gregory Brown, MD, PhD, Department of Medicine, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania; Sol De Jesus, MD, Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania; Emily Leboffe, MD, Department of Medicine, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania; Andy Esch, MD, Center to Advance Palliative Care, New York, New York; and Kristina Newport, MD, Department of Medicine, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Goals: Advance care planning (ACP) procedure codes have been established to reimburse meaningful care goal discussions; however, the utilization frequency of these codes in neurological disease is unknown. The objective of this study is to identify the association between ACP codes and healthcare utilization in chronic neurodegenerative diseases.
Methods: This is a multicenter cohort study using real-world electronic health data.
Longitudinal Trajectory of Dopamine and Serotonin Transporters in Parkinson Disease.
J Nucl Med
January 2025
Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Parkinson disease (PD) is a multisystem disorder marked by progressive dopaminergic neuronal degeneration in the substantia nigra, as well as nondopaminergic systems. Our aim was to investigate longitudinal changes in -(3-[F]fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (F-FP-CIT) binding at the putamen, substantia nigra, and raphe nuclei in PD. This retrospective cohort study enrolled 127 patients with PD, who underwent F-FP-CIT PET scans twice or more, and 71 age- and sex-matched healthy controls.
View Article and Find Full Text PDFThe role of microglia in Neuroinflammation associated with cardiopulmonary bypass.
Front Cell Neurosci
December 2024
Department of Trauma Center, The First Affiliated Hospital of China Medical University, Shenyang, China.
Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are indispensable core techniques in cardiac surgery. Numerous studies have shown that cardiopulmonary bypass and deep hypothermic circulatory arrest are associated with the occurrence of neuroinflammation, accompanied by the activation of microglia. Microglia, as macrophages in the central nervous system, play an irreplaceable role in neuroinflammation.
View Article and Find Full Text PDFAdvances in Parkinson's Disease Diagnosis Through Diffusion Kurtosis Imaging and Radiomics.
Acad Radiol
December 2024
Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St. Louis, MO (A.N.). Electronic address:
Indoles as promising Therapeutics: A review of recent drug discovery efforts.
Bioorg Chem
December 2024
Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India.
Indole, a fundamental heterocyclic core, has emerged as a cornerstone in the medicinal chemistry due to its diverse biological activities and structural versatility. This aromatic compound, present in natural as well as synthetic compounds, offers a versatile platform for the drug discovery. By strategically incorporating functional groups or pharmacophores, researchers can tailor indole-derivatives to target a wide range of diseases.
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