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Impact of CDA Dynamics on Clinical Outcome of Patients With AML or High-Risk MDS Treated With Nucleoside Analogs.
Hematol Oncol
March 2025
Hematology and Cellular Therapy Department, La Conception University Hospital of Marseille, Marseille, France.
Novel repetitive elements in plant-specific tails of Gγ proteins as the functional unit in G-protein signalling in crops.
Plant Cell
March 2025
National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research (Wuhan), Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.
Heterotrimeric G proteins act as molecular switches in signal transduction in response to stimuli in all eukaryotes. However, what specifies G protein signalling in plants and how the mechanism evolved and diverged remain unsolved. Here, we found that the recently evolved tails of three Gγ subunits, Dense and erect panicle 1 (DEP1), G protein gamma subunit 2 of type C (GGC2), and Grain size 3 (GS3), determine their distinct functions and specify grain size in rice (Oryza sativa L.
View Article and Find Full Text PDFArtificial Intelligence for Patient Support: Assessing Retrieval-Augmented Generation for Answering Postoperative Rhinoplasty Questions.
Aesthet Surg J
March 2025
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA.
Background: While artificial intelligence (AI) is revolutionizing healthcare, inaccurate or incomplete information from pre-trained large language models (LLMs) like ChatGPT poses significant risks to patient safety. Retrieval-Augmented Generation (RAG) offers a promising solution by leveraging curated knowledge bases to enhance accuracy and reliability, especially in high-demand specialties like plastic surgery.
Objectives: This study evaluates the performance of RAG-enabled AI models in addressing postoperative rhinoplasty questions, aiming to assess their safety and identify necessary improvements for effective implementation into clinical care.
Lead-Based Perovskites Significantly Suppress Dark Currents toward High-Performance Multilayer SnS/Perovskite Photodetectors.
ACS Nano
March 2025
School of Microelectronics, Northwestern Polytechnical University, Xi'an 710072, China.
Tin disulfide (SnS), a layered material analogous to two-dimensional transition metal dichalcogenides (TMDs), demonstrates excellent photoresponse capabilities. However, the relatively large dark current in multilayer SnS photodetectors limits their potential in high-performance photodetection. To address this issue, we introduce lead (Pb)-based halide perovskites as dark current suppression layers for the SnS photodetector.
View Article and Find Full Text PDFMitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells.
Cell Rep
March 2025
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:
Genetic and environmental factors shape an individual's susceptibility to autoimmunity. To identify genetic variations regulating effector T cell functions, we used a forward genetics screen of inbred mouse strains and uncovered genomic loci linked to cytokine expression. Among the candidate genes, we characterized a mitochondrial inner membrane protein, TMEM11, as an important determinant of Th1 responses.
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