Twelve new compounds, named fuscoposides A -L (1-12), including two phenolic, nine benzenoid, and one phenylethanoid glucosides, were isolated from the mangrove endophytic fungus Fuscoporia sp. A2A6. The structures of these compounds were established by HRESIMS, NMR spectroscopic data, single-crystal X-ray diffraction analysis, and chemical methods. Most notably, ten compounds, viz. fuscoposides A-J (1-9) and fuscoposide L (12), are mono- or di-chlorinated. Fuscoposide C (3) exhibited moderate neuroprotective effects against H2O2-induced oxidative damage in mouse hippocampal neuron HT-22 cells in a dose-dependent manner at the concentration range of 2.0-6.0 μM, whereas fuscoposide G (7) decreased the expression of COX2 in LPS-stimulated mouse microglia BV2 cells at the concentration of 5.0 μM, thereby displaying anti-inflammatory activity.
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