A 12-year-old terrier was referred for investigation of a 4-month history of coughing, sneezing and nasal discharge. Clinical findings were consistent with sinonasal Aspergillus fumigatus infection with evidence of intracranial extension on computed tomography. Endoscopic debridement followed by topical clotrimazole and systemic antifungal therapy resulted in clinical improvement. Magnetic resonance imaging after 4 weeks showed reduced intracranial disease but demonstrated evidence of temporal myositis. Repeated debridement and topical treatment were performed at 4 and 8 weeks in conjunction with long-term voriconazole therapy. Further interventions were declined; the dog remains clinically well after 4 months with unilateral nasal discharge. As in human patients, invasive subtypes of sinonasal aspergillosis may also occur in dogs and be associated with poorer response to treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683769 | PMC |
| http://dx.doi.org/10.1002/vms3.70188 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Case of Canine Sinonasal Aspergillus fumigatus Infection Associated With Intracranial Extension and Temporal Myositis.
Vet Med Sci
January 2025
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
A 12-year-old terrier was referred for investigation of a 4-month history of coughing, sneezing and nasal discharge. Clinical findings were consistent with sinonasal Aspergillus fumigatus infection with evidence of intracranial extension on computed tomography. Endoscopic debridement followed by topical clotrimazole and systemic antifungal therapy resulted in clinical improvement.
View Article and Find Full Text PDFChronic Granulomatous Invasive Fungal Rhinosinusitis With Intracranial Extension in an Immunocompetent Patient: A Case Report.
Cureus
October 2024
Otorhinolaryngology, University of Pretoria, Pretoria, ZAF.
Article Synopsis
- - Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is a rare disease affecting immunocompetent individuals, primarily caused by fungi from the Aspergillus species.
- - It can be confused with sinonasal cancers due to its aggressive nature; the article discusses a specific case of CGIFRS in an immunocompetent male that extended into the brain.
- - The patient was successfully treated with antifungals following surgical intervention, highlighting the importance of accurate diagnosis and management, as this is the first reported case of CGIFRS with intracranial extension in South Africa.
Use of intranasal povidone-iodine packing in the management of infectious rhinosinusitis in three cats.
JFMS Open Rep
November 2024
Capital Veterinary Specialists, Tallahassee, FL, USA.
Case Series Summary: Described are three cats diagnosed with rhinosinusitis secondary to , species and species, respectively. Medical records were retrospectively reviewed to identify cats with decreased nasal airflow and mucopurulent discharge that failed to improve on antibiotic therapy of 3 months or longer duration. Surgical debridement was followed by nasal packing using 5% povidone-iodine saturated umbilical tape, which was replaced at 24 h postoperatively.
View Article and Find Full Text PDFChronic Invasive Fungal Sinusitis Mimicking Malignancy Post-Radiotherapy: A Case Report.
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Otorhinolaryngology and Head and Neck Surgery, Changi General Hospital, Singapore, 2 Simei Street 3, Singapore, 529889 Singapore.
Article Synopsis
- Invasive fungal sinusitis is a severe condition that can be mistaken for cancer, especially in patients who have had radiation therapy for head and neck cancers.
- A case study of a 68-year-old man, who developed symptoms of invasive fungal sinusitis 25 years after treatment for nasopharyngeal carcinoma, illustrates the challenges in diagnosing this condition.
- The report emphasizes the importance of histological examination to confirm diagnosis and suggests that repeat imaging and evaluations may be necessary to avoid misdiagnosis.
Dual blockade of IL-4 and IL-13 with dupilumab ameliorates sensorineural olfactory dysfunction in mice with eosinophilic sinonasal inflammation.
Rhinology
September 2024
School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Background: Dupilumab, an antibody that binds IL-4Rα and inhibits IL-4 and IL-13 signals, has demonstrated efficacy in chronic rhinosinusitis with nasal polyps (CRSwNP) primarily characterized by type 2 inflammation. Current evidence suggests that the rate of improvement in olfactory dysfunction with dupilumab exceeds that of nasal polyp reduction, yet the underlying mechanism remains undisclosed. We hypothesize that dupilumab may initially ameliorate sensorineural olfactory dysfunction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!