AI Article Synopsis
- Transthyretin amyloidosis (ATTR) is a condition caused by unstable transthyretin protein (TTR) building up in the heart and nerves.
- Therapeutic approaches focus on lowering TTR levels by inhibiting its production in the liver and clearing amyloid deposits from tissues.
- The article also explores TTR's role in disease development, recent treatment advancements, and future research opportunities for better diagnosis and prevention.
Article Abstract
Transthyretin amyloidosis (ATTR) is characterized by the deposition of unstable transthyretin protein (TTR) in the heart or peripheral nerves. Therapeutic strategies for ATTR include inhibition of the secretion of abnormal TTR by the liver, reducing the concentration of aberrant TTR in the circulation, and eliminating amyloid deposits of TTR in tissues. This article delves into the pathogenesis of TTR secretion from the liver into the bloodstream, its deposition in tissues, and the subsequent development of ATTR. Additionally, we delineated the advancements in treatment strategies and discussed future research directions to provide novel insights for the identification of diagnostic and preventive targets.
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| http://dx.doi.org/10.1097/FJC.0000000000001663 | DOI Listing |
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