Therapeutic Efficacy of Salvia chudaei Ethanol Extract in Hyperlipidemia, Hyperglycemia, and Oxidative Stress in Triton X-100-Induced Wistar Rats.

The study explored the efficacy of Salvia chudaei ethanolic extract in managing hyperlipidemia, hyperglycemia, and oxidative stress induced by Triton X-100 in Wistar rats. Twenty-four rats were divided into four groups: Control, Salvia chudaei-treated, Triton-induced hyperlipidemic, and a combination of Triton + Salvia chudaei treatment. Triton X-100 raised serum levels of total cholesterol, triacylglycerol, and LDL while lowering HDL cholesterol, leading to oxidative stress marked by increased MDA and reduced antioxidant activity in liver and kidney tissues. Administration of Salvia chudaei extract effectively reversed these adverse effects, significantly lowering cholesterol, triacylglycerol, and LDL levels, and improving HDL cholesterol. It also enhanced antioxidant defenses and reduced oxidative stress markers, demonstrating its protective role against metabolic dysfunction. HPLC analysis confirmed the presence of bioactive compounds in the extract that contribute to these benefits. The findings suggest that Salvia chudaei ethanolic extract possesses strong antihyperlipidemic, antihyperglycemic, and antioxidant properties, making it a promising natural agent for preventing and treating hyperlipidemia and oxidative stress. This positions Salvia chudaei as a potential new therapeutic approach in the management of metabolic disorders.