Normal anal sensibility can be present in ARM patients diagnosed with all types of ARM after they have been treated with corrective surgery. Anal sensibility was better in those with a functional IAS. This means that the IAS, present in the distal end of the fistula, should be spared as much as possible to preserve anal sensibility. In this way, aiming to maintain the best possible fecal continence. Furthermore, the outcomes of this study demonstrate that anal sensibility is regulated by transmural nerves.
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http://dx.doi.org/10.1111/nmo.14983 | DOI Listing |
Neurogastroenterol Motil
December 2024
Department of Surgery, Anorectal Physiology Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Normal anal sensibility can be present in ARM patients diagnosed with all types of ARM after they have been treated with corrective surgery. Anal sensibility was better in those with a functional IAS. This means that the IAS, present in the distal end of the fistula, should be spared as much as possible to preserve anal sensibility.
View Article and Find Full Text PDFActa Anal
September 2024
Department of Philosophy and Department of Public Policy, Central European University (CEU), Quellenstrasse 51, 1100 Vienna, Austria.
In this article, I explore an epistemic vice I call "evidential incognizance." It is a vice of failing generally to recognize evidence, or recognize the full force of evidence, in a domain of knowledge. It frequently manifests as a kind of unbridled skepticism or hopelessness about knowing in the domain, including (but not limited to) skepticism about expert testimony.
View Article and Find Full Text PDFAnal Chem
October 2024
Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, Yancheng Institute of Technology, Yancheng 224051, China.
The exploitation of small molecules as fluorescence sensors represents a minimalistic solution toward the sensing of hazardous volatile organic compounds (VOCs). Compared with the conventional aggregation-induced emitting sensors, the carborane (Cb)-based sensors have exhibited multiple advantages and improved quantitative fluorescence (QF) sensing abilities toward the gaseous VOCs. However, in the current Cb-based sensors, the localization of a single responsive site toward VOCs remains less focused, which results in a bias in the trace detection and short-range testing windows.
View Article and Find Full Text PDFAnal Chem
May 2024
Embrapa Instrumentação Agropecuária, 13560-970 São Carlos, Brazil.
Nuclear magnetic resonance (NMR) longitudinal rotating frame relaxation time (T), rarely used in low-field NMR, can be more effective than conventional T and T relaxation times to differentiate polymorphic forms of solid pharmaceuticals. This could be attributed to T sensibility to structural and molecular dynamics that can be enhanced by changing the strength of the oscillating magnetic field () of spinlock pulses. Here, we compared the capacity of T, T, and T to differentiate inactive (A) and active (C) crystalline forms of the World Health Organization essential drug Mebendazole.
View Article and Find Full Text PDFAnal Chem
April 2024
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
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