The coordinated development of water, energy, and food (WEF) is crucial to the fate and overall development plan of China in the new era. The aim of this study is to examine the coupling coordination of China's inter-provincial WEF security system, by using comprehensive development index model, coupling coordination model, the GM (1,1) gray forecast model, and China's provincial panel data from 2004 to 2021. The results of the study showed that the coupling coordination of China's inter-provincial WEF security system has significantly improved, adjusting from a near imbalance in 2004 to a good coupling coordination state in 2021. As of 2021, 13 provinces in China have entered a state of good coupling coordination. The forecast results display that the coupling coordination level of China's WEF security will show a significant upward trend from 2022 to 2030. By 2030, 22 provinces in the country are expected to achieve good coupling coordination or above. And 13 of these countries will achieve a high-quality coupling coordination.
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http://dx.doi.org/10.1007/s11356-024-35789-z | DOI Listing |
Coordination between growth and division is a fundamental feature of cells. In many syncytia, cell growth must couple with multiple nuclear divisions in one cytoplasm. In the fungus, cell-cycle progression and hyphal elongation require condensates formed by the protein Whi3 in complex with distinct mRNA species.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
We report a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ- and δ,ε-alkenylamines with aryl halides and alkylzinc reagents. The reaction is enabled by amine coordination and can use all primary, secondary, and tertiary amines. The reaction constructs two new C(sp)-C(sp) and C(sp)-C(sp) bonds and produces δ- and ε-arylamines with C(sp)-branching at the γ- and δ-positions.
View Article and Find Full Text PDFNat Med
January 2025
Department of Medicine-Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.
View Article and Find Full Text PDFJ Phys Chem A
January 2025
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
We revisit the naked transition metal cation (Ti) and methanol reaction and go beyond the standard Landau-Zener (LZ) picture when modeling the intersystem crossing (ISC) rate between the lowest doublet and quartet states. We use both (i) unconstrained Born-Oppenheimer molecular dynamics (BOMD) calculations with an approximate two-state method to estimate population transfer between spin diabats and (ii) constrained dynamics to explore energetically accessible portions of the - 1 crossing seam, where is the total number of internal degrees of freedom. Whereas previous LZ calculations (that necessarily relied on the Condon approximation to be valid) fell short and predicted much slower crossing probabilities than shown in experiment, we show that ISC can occur rapidly because the spin-orbit coupling (SOC) between the doublet and quartet surfaces can vary by 2 orders of magnitude (depending on where in the seam the crossing occurs during dynamics) and the crossing region is revisited multiple times during a dynamics run of a few hundred femtoseconds.
View Article and Find Full Text PDFInt Arch Occup Environ Health
January 2025
Coordination for the Innovation and Application of Science and Technology (CIACYT), Autonomous University of San Luis Potosi, Sierra Leona Avenue No. 550, Lomas Second Section, San Luis Potosi, C.P. 78210, SLP, Mexico.
Purpose: Individuals in occupational environments are particularly susceptible to the impacts of pollutants; making it crucial to assess systemic inflammation markers. The study aimed to evaluate the immune response to inflammation through the assessment of a cytokine profile in individuals working in vulnerable conditions exposed to heavy metals.
Methods: A total of 137 adults participated in this study from three work environments: brickyards, waste scavenging and quarries.
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