The Tibetan Plateau is home to numerous glaciers that are important for freshwater supply and climate regulation. These glaciers, which are highly sensitive to climatic variations, serve as vital indicators of climate change. Understanding glacier-fed hydrological systems is essential for predicting water availability and formulating climate adaptation strategies. This study investigated the dynamic fluctuations in the water level of the Blue Moon Lake Valley (BMLV), supplied by meltwater from Baishui River Glacier No. 1 on Yulong Snow Mountain. We focused on the lake pulse phenomenon-subtle yet significant water level fluctuations that have often been overlooked in prior research. By employing fast Fourier transform (FFT), multivariate regression (MVR), and random forest (RF) models, we examined the interactions among glacier melt dynamics, climatic variables, and hydrological responses. Our analysis indicates that the rate of change (ROC) in the water level fluctuates between - 0.006 and 0.01 m/min, with a median ROC of - 7.24E-06 m/min, highlighting the significant variability influenced by glacier melt and precipitation. The maximum cumulative sum (CS) value of 0.09 m suggests a net increase in the water level, predominantly due to increased precipitation, decreased evaporation, and increased glacier melting. We demonstrate that temperature critically influences glacier melt rates and water level variations, alongside solar radiation, rainfall, atmospheric pressure, and wind speed. The ROC of Baishui River Glacier No. 1 melt ranges from - 0.0016 to 0.0015 m/min, reflecting substantial variation with significant downstream implications for water availability during dry seasons. The mean interval between consecutive glacier melt peaks is approximately 2.87 h, with a strong positive linear trend R = 0.99, indicating frequent melt events. Conversely, water level peaks occur approximately every 6.5 h, with a strong positive trend R = 0.99, indicating a slower recurrence rate. The transit time for meltwater from Baishui River Glacier No. 1 to BMLV is estimated at approximately 4.16 h. Additionally, we quantify the water flux from BMLV across various timescales, highlighting the substantial contribution of glacial meltwater. This novel study systematically examines the hydrological dynamics of BMLV. This study has the potential to reveal broader implications for water resource management, ecosystem dynamics, and climate change adaptation in regions dependent on glacier-fed lakes.
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Inflammopharmacology
January 2025
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, 63100, Pakistan.
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, gastric disorders, and as an analgesic. Chemo-herbal combinations are known to have potent anti-inflammatory and analgesic effects, while mitigating the drug related side effects.
View Article and Find Full Text PDFNeurochem Res
January 2025
Department of Radiology, the Second Affiliated Hospital of Kunming Medical University, No.374 Yunnan-Burma Road, Wuhua District, Kunming, Yunnan, 650101, PR China.
Objective: Post-resuscitation brain injury is a common sequela after cardiac arrest (CA). Increasing sirtuin1 (SIRT1) has been involved in neuroprotection in oxygen-glucose deprivation (OGD) neurons, and we investigated its mechanism in post-cardiopulmonary resuscitation (CPR) rat brain injury by mediating p65 deacetylation modification to mediate hippocampal neuronal ferroptosis.
Methods: Sprague-Dawley rat CA/CPR model was established and treated with Ad-SIRT1 and Ad-GFP adenovirus vectors, or Erastin.
Environ Geochem Health
January 2025
Nuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology, Nakhon Nayok, 26120, Thailand.
The present study aimed to investigate the hydrogeochemical patterns and contamination of the radiogeology, especially radon activity, related to geothermal aquifer properties and to perform a risk assessment of annual effective doses covering all hydrothermal spring attractions in Southern Thailand. Radon is an established lung carcinogen; especially longer term exposure to radioactive radon through inhalation could be a cause of lung cancer risk. Altogether 22 hydrothermal spring samples were collected from the six hydrothermal provinces in Southern Thailand in early November of 2023.
View Article and Find Full Text PDFMar Biotechnol (NY)
January 2025
Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
Burn wounds are challenging to treat due to considerable tissue damage and fluid loss. Creating wound dressings from natural and biological materials makes it possible to treat wounds and promote rapid epithelialization to speed healing and restore skin function. As a result, the ability of a collagen scaffold (Col) made from rainbow trout (Oncorhynchus mykiss) and putative bioactive phytochemical components from a Sargassum glaucescens (S.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.
Background: Soluble Aβ oligomers (AβOs) induce synapse dysfunction, leading to cognitive impairment and memory deficits in Alzheimer's disease (AD). Our laboratory and several research groups characterized neurexin family members' physiological roles, pivotal synaptic adhesion molecules for development, plasticity, and maintenance. Beyond their normal functions, we found neurexins binding to AβOs causes AβO-induced neurexin dysregulation.
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