Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.25259/IJMR_350_2024 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683528 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Albany Medical College, Albany, NY, USA.
Background: About two-thirds of those with Alzheimer's disease (AD) are women, most of whom are post-menopausal. Menopause accelerates the risk for dementia by increasing the risk for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic disease (e.
View Article and Find Full Text PDFThe new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis.
J Enzyme Inhib Med Chem
December 2025
Department of Organic Chemistry, Medical University of Lublin, Lublin, Poland.
The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties . Here, we report the design and synthesis of a number of new derivatives inspired by the structure of thiazolidine-2,4-dione (TZD).
View Article and Find Full Text PDFA new peptide inhibitor of C1QBP exhibits potent anti-tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair.
Clin Transl Med
January 2025
Department of Breast, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
C1QBP exhibits heightened expression across a spectrum of tumours, thereby fostering their proliferation and metastasis, rendering it a pivotal therapeutic target. Nevertheless, to date, no pharmacological agents capable of directly targeting and inducing the degradation of C1QBP have been identified. In this study, we have unveiled a new peptide, PDBAG1, derived from the precursor protein GPD1, employing a peptidomics-based drug screening strategy.
View Article and Find Full Text PDFModeling synergy and individual effects of X-ray induced photodynamic therapy components.
Sci Rep
January 2025
Department of Medical Physics, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran.
X-ray induced photodynamic therapy (XPDT) utilizes self-lighting nanoparticles to combine the benefits of radiotherapy and photodynamic therapy. These nanomaterials transform X-ray to visible light that can be absorbed by nearby photosensitizers and in the presence of surrounding oxygen molecules generates reactive oxygen species, which are very toxic to the cells. Despite many studies conducted on modelling XPDT, little focused on the contribution of each component as well as their synergy effects.
View Article and Find Full Text PDFTYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis.
J Cancer
January 2025
The Colorectal and Anal Surgery Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
Thymidylate synthase (TYMS) is a key regulatory enzyme in DNA synthesis. We identified the biological effect and molecular mechanisms of TYMS in colorectal cancer (CRC). We employed western blot and immunohistochemistry for the assessment of TYMS expression in CRC samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!