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Fungal infection in patients treated with Bruton's Tyrosine Kinase inhibitor, from epidemiology to clinical outcome: A systematic review.
Clin Microbiol Infect
December 2024
Sorbonne Université, CIMI-Paris, AP-HP, Service de Parasitologie-Mycologie, Hopital de La Pitie-Salpetriere, F-75013 Paris, France. Electronic address:
Background: Bruton Tyrosine Kinase inhibitor (BTKi) emerged as key treatment for B-cell lymphomas. Despite its efficacy in the treatment of malignancies, numerous cases of invasive fungal infections (IFI) have been reported in patients receiving ibrutinib, a first generation BTKi. Cases of invasive aspergillosis have also been reported with acalabrutinib and zanubrutinib.
View Article and Find Full Text PDFHow to Get It Right: A New Series in CMI on Scientific Methodology, Practice, and Avoiding Common Mistakes.
Clin Microbiol Infect
December 2024
University of Amsterdam, Epidemiology and Data Science.
Trends in antimicrobial consumption: long-term impact of the COVID-19 pandemic.
Clin Microbiol Infect
December 2024
AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Objectives: The COVID-19 pandemic was associated with a global decrease in antimicrobial consumption (AMC) in 2020. However, the persistence of this downwards trend is not known at a global level. This study examined the global and longer-term trends in AMC after the emergence of COVID-19.
View Article and Find Full Text PDFImmuno-persistence after the fourth and fifth doses of inactivated polio vaccines in school-aged children.
Clin Microbiol Infect
October 2024
The Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, P. R. China; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, P. R. China; Laboratory of Data Discovery for Health Limited (D(2)4H), Hong Kong Science Park, Hong Kong Special Administrative Region, P. R. China; The University of Hong Kong-Shenzhen Hospital, Shenzhen, P. R. China.
Objectives: This study aimed to assess the long-term persistence of neutralizing antibodies (nAb) titres and seroprotection proportions after the fourth and fifth doses of inactivated polio vaccine (IPV).
Methods: Serum samples from 299 children in Hong Kong were collected and used to estimate the persistence of nAb titres and seroprotection proportions by neutralisation test.
Results: The mean nAb titres against poliovirus types 1, 2, and 3 (PV1, PV2, and PV3) 1 month after receiving the fourth dose of IPV at 19 months of age were 2068 (95% credible interval, 1517-2864); 4705 (3439-6436); and 2758 (1894-4086); respectively, but declined substantially in 4 years to 268 (222-325), 751 (630-900), and 411 (323-521), respectively.
Effectiveness of the enterovirus A71 vaccine on hand, foot, and mouth disease: a real-world study in China.
Clin Microbiol Infect
September 2024
Department of Epidemiology and Health Statistics, School of Public Health, Fudan University, Shanghai, China; Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. Electronic address:
Article Synopsis
- The study evaluates the effectiveness of enterovirus A71 (EV-A71) vaccines in reducing hand, foot, and mouth disease (HFMD) cases among children under 5 in China, with analysis based on surveillance data and statistical models.
- Findings show that between 2017 and 2018, vaccination led to a significant reduction in HFMD incidence, with a relative risk of 0.83, translating to about 298,000 fewer cases.
- The effectiveness of the vaccine varied by region, was better in areas with higher vaccination coverage (above 20%), and decreased in more densely populated areas, highlighting the need for improved vaccination strategies.
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