Introduction: Facial burn injuries can compromise the airways in pediatric patients. Because prompt assessment of airway safety is a must, most assessment algorithms rely mainly on clinical judgment. There is little data on the value or utility of Fiber Optic Laryngoscopy (FOL) as an ancillary test.
Method: This retrospective analysis covered data from patients' charts at Hadassah Medical Center of all children aged 0-18 years who presented at the pediatric emergency department for facial burns and underwent FOL from January 2010 to December 2022.
Results: Over this 12-year period, 149 children were referred to the PED with scald or flash facial burns and underwent a documented FOL. Overall, there were more males than females (102; 68.4 %). There were significantly more scald burns than flash burns in toddlers (aged 2.16 ± 2.43 years; 103, 69 %). Flash burns predominated in older children (46, 30.8 %). Of the cohort, 28 (27 %) patients were admitted to the Pediatric Intensive Care Unit for scald burns and 10 (22 %) for flash burns. Findings consistent with inhalation injury identified during the FOL examination were found in 11 (7.3 %) children. The clinical finding of inhalation injury was confirmed in 17 (11.4 %) of the cases. Of these, 5 (45.5 %) had positive clinical findings suggestive of inhalation injury and 6 (54.5 %) had normal physical exam. Intubation was performed in 10 (6.7 %) of the cases. FOL had sensitivity of 29 % and specificity of 95 % for clinical findings, with NPV of 91 %.
Conclusion: The study findings suggest that the use of FOL examination in pediatric patients with facial burns and clinical signs suggestive of inhalation injury may have value, whereas its routine use presents low sensitivity comparable to reliance on clinical findings alone. Thus, FOL should be used in the patients with clinical signs of inhalation injury.
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http://dx.doi.org/10.1016/j.ajem.2024.12.064 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Kerman university of Medical Sciences, Kerman, Iran.
Lung Ischemia-reperfusion injury (LIRI) is a risk during lung transplantation that can cause acute lung injury and organ failure. In LIRI, the NF-E2-related factor 2(Nrf2)/ Kelch-like ECH-associated protein 1 (Keap1) signaling pathway and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway are two major pathways involved in regulating oxidative stress and inflammation, respectively. Myrtenol, a natural compound with anti-inflammatory and antioxidant properties, has potential protective effects against IRI.
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December 2024
Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Radon (Rn) is a naturally occurring radioactive gas, ionizing radiation emitted by the radon induces oxidative stress and the up-regulation of inflammatory proteins, which may cause lung damage or cancer. However, the underlying pathogenesis remains to be determined. effector T helper cells are key in mediating the host's protection and immune homeostasis.
View Article and Find Full Text PDFJ Occup Environ Med
January 2025
From the Centre for Fire and Hazards Sciences, University of Central Lancashire, Preston, Lancashire, United Kingdom.
Objective: This study aimed to characterize the smoke exposure of firefighters who attended the Grenfell Tower fire during the initial 20 hours.
Methods: As no compilation of exposure data exists, data were compiled from nine unconnected sources, including the Grenfell Tower Inquiry, firefighters' statements, incident logs, and the UK Firefighter Cancer and Disease Registry.
Results: Of the 628 firefighters who attended, information was available from 524.
Int Marit Health
January 2025
National Centre for Hyperbaric Medicine, Institute of Maritime and Tropical Medicine in Gdynia, Medical University of Gdansk, Poland.
Medical hyperbaric sessions for Hyperbaric Oxygen Therapy, conducted at 2.4-2.5 ATA for 80 to 120 minutes, expose staff to increased risk of DCS due to the inhalation of compressed air, which increases gas solubility in body fluids as per Henry's Law.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China. Electronic address:
Co-exposure to ground-level ozone (O) and fine particles (PM, ≤ 2.5 µm in diameter) has become a primary scenario for air pollution exposure of urbanites in China. Recent studies have suggested a synergistic effect of PM and O on induction of lung inflammatory injury.
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