German energy system studies, investigating the energy transition pathways to the set climate targets, depict a significant decrease in gas demand. This leads to a discussion about the long-term need of gas distribution networks. The discussion intensified with the war in Ukraine and the subsequent energy price crisis. The German regulatory agency responded to these developments with adjusting the regulatory framework to the current challenges. Up to now, the depreciation period of network components varies between 45 and 65 years, and consequently the monetary capital is tied up for a long time, lowering the flexibility of network operators to react to current challenges. Therefore, the German regulatory agency allows the shortening of depreciation periods of new gas network assets. Nonetheless, it is still unclear how to deal with existing assets at risk of becoming stranded assets and how to regulate the decommissioning of gas networks. Therefore, this paper addresses the research question: "What effect do different regulations for decommissioning of gas distribution networks have on operators and users?". To answer the question the model MERLIN is applied, which integrates the current and future regulation options into long-term investment decision analysis. The results show a need to shorten the depreciation period of existing assets to avoid stranded assets. Further, partial decommissioning with including the decommission costs in the regulatory framework and hence finance it through the network users, is the most economical attractive option for network operators and users.
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http://dx.doi.org/10.1016/j.heliyon.2024.e40800 | DOI Listing |
Glob Chang Biol
January 2025
Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic.
Climate change poses an unprecedented threat to forest ecosystems, necessitating innovative adaptation strategies. Traditional assisted migration approaches, while promising, face challenges related to environmental constraints, forestry practices, phytosanitary risks, economic barriers, and legal constraints. This has sparked debate within the scientific community, with some advocating for the broader implementation of assisted migration despite these limitations, while others emphasize the importance of local adaptation, which may not keep pace with the rapid rate of climate change.
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December 2024
Law, Gujarat National Law University, Ahmedabad 382426, Gujarat, India.
The Johnson and Johnson faulty hip implant case represents one of the most significant crises in medical device history, impacting nearly 93000 patients worldwide. In response to alarming failure rates and a global recall in August 2010, countries such as Australia, the United States, and the United Kingdom quickly implemented revision surgeries and reimbursement programs to protect patient safety. In stark contrast, India's response was alarmingly delayed; defective implants continued to be sold even after the global recall.
View Article and Find Full Text PDFEnviron Pollut
December 2024
Marine College, Shandong University, Weihai, Shandong, 264209, China. Electronic address:
Artificial reefs (ARs) are an important means of improving marine ecological environments and promoting the sustainable use of marine biological resources. After AR deployment, biological communities undergo dynamic changes as species succession and shifts in community structure. As the most sensitive frontier affected by the environment, the complex and dynamic changes of microbial communities play a crucial role in the health and stability of the ecosystem.
View Article and Find Full Text PDFValue Health
December 2024
CHOICE Institute, School of Pharmacy, University of Washington, Seattle, WA, USA.
Objective: Recent scientific breakthroughs have propelled the development of disease-modifying and potentially curative cell and gene therapies (CGTs) for rare diseases, including those diseases previously considered untreatable. However, the unique characteristics of CGTs pose challenges for the traditional methods of therapy value determination, reimbursement, and outcome evaluation used by regulatory and assessment agencies for product approval and market access. Notably, CGTs are one-time or short-course treatments, often first-in-class (precluding direct comparisons with effective alternatives), and have health benefits that are largely realized over time.
View Article and Find Full Text PDFSemin Immunol
December 2024
Department of Immunology, Leiden University Medical Center, Leiden, Netherlands. Electronic address:
The complement system plays an integral role in both innate and adaptive immune responses. Beyond its protective function against infections, complement is also known to influence tumor immunity, where its activation can either promote tumor progression or mediate tumor cell destruction, depending on the context. One such context can be provided by antibodies, with their inherent capacity to activate the classical complement pathway.
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