Depression is a complex mental health condition characterized by persistent sadness, loss of interest, and a range of cognitive, emotional, and behavioral symptoms. It can be acute or chronic and is often influenced by a combination of genetic, biological, psychological, and social factors. According to transnational estimates of prevalence, depressive symptoms represent the most concerning challenge to mental health across cultures and beyond geographical borders. There are growing public health concerns that depression is leading to an increase in suicide rates, while causing diversity, uncertainty of treatment options and cultural stigma. The current trends in life expectancy make depression a great challenge for global health, while there are unsolved care problems on how to implement adequate responses and treatment at local and global levels. The main purpose of this article is to highlight why an integrated path to care is more critical than ever before. The role of biomedical sciences and modern psychology is therefore discussed in terms of how developing our knowledge may better help us to support those with depression, and to inspire new research methods in primary and secondary care.
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http://dx.doi.org/10.7759/cureus.74566 | DOI Listing |
Stroke
January 2025
Neurology, Stroke, University Hospital Cleveland Medical Center - Case Western Reserve University, OH. (A.O., C.S., A.S.).
Background: Several social and biological factors are shown to differentially affect stroke outcomes between men and women. We evaluated whether clinical outcomes and endovascular thrombectomy (EVT) treatment effects differed between the sexes in patients presenting with large ischemic stroke.
Methods: The SELECT2 trial (A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke) was a randomized controlled trial assessing the efficacy and safety of EVT in patients with large strokes across the United States, Canada, Europe, Australia, and New Zealand between October 2019 and September 2022.
Emerg Med Australas
February 2025
Centre for Adolescent Health, Murdoch Children's Research Institute and Royal Children's Hospital, Melbourne, Victoria, Australia.
Objectives: Somatic symptom and related disorders (SSRDs) are complex disorders that are commonly encountered in tertiary paediatric settings. Despite this, little is known about ED use prior to hospital admission. We aimed to describe the pattern of ED use in a cohort of children and adolescents who were subsequently admitted to hospital with SSRD and to identify factors associated with ED presentations.
View Article and Find Full Text PDFSociol Health Illn
January 2025
Department of Gerontology, University of Southampton, Southampton, UK.
Decisions about ethnic groups studied in health research shape recommendations. If a group is not included in research, its ability to call for policy change is limited. Despite health inequalities for the Irish in Britain in the 20th century, recent research on health is likely to combine the White Irish with White British, whereas Irish people of colour are not mentioned at all.
View Article and Find Full Text PDFWorld J Orthop
December 2024
Department of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Background: Arthritis is a prevalent and debilitating condition that affects a significant proportion of middle-aged and older adults worldwide. Characterized by chronic pain, inflammation, and joint dysfunction, arthritis can severely impact physical function, quality of life, and mental health. The overall burden of arthritis is further compounded in this population due to its frequent association with depression.
View Article and Find Full Text PDFTheranostics
January 2025
Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
: The periaqueductal gray (PAG) is a central hub for the regulation of aggression, whereas the circuitry and molecular mechanisms underlying this regulation remain uncharacterized. In this study, we investigate the role of a distinct cell type, -expressing (Tac2) neurons, located in the dorsomedial PAG (dmPAG) and their modulation of aggressive behavior in mice. : We combined activity mapping, Ca recording, chemogenetic and pharmacological manipulation, and a viral-based translating ribosome affinity purification (TRAP) profiling using a mouse resident-intruder model.
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