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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681184 | PMC |
| http://dx.doi.org/10.12336/biomatertransl.2024.03.009 | DOI Listing |
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Targeting tumour-osteoclast interactions: a trigger-explosion system to combat bone metastasis.
Biomater Transl
September 2024
Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China.
Targeting initial tumour-osteoclast spatiotemporal interaction to prevent bone metastasis.
Nat Nanotechnol
July 2024
Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Bone is the most common site of metastasis, and although low proliferation and immunoediting at the early stage make existing treatment modalities less effective, the microenvironment-inducing behaviour could be a target for early intervention. Here we report on a spatiotemporal coupling interaction between tumour cells and osteoclasts, and named the tumour-associated osteoclast 'tumasteoclast'-a subtype of osteoclasts in bone metastases induced by tumour-migrasome-mediated cytoplasmic transfer. We subsequently propose an in situ decoupling-killing strategy in which tetracycline-modified nanoliposomes encapsulating sodium bicarbonate and sodium hydrogen phosphate are designed to specifically release high concentrations of hydrogen phosphate ions triggered by tumasteoclasts, which depletes calcium ions and forms calcium-phosphorus crystals.
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