Small-Bowel Metastatic Melanoma From Primary Mucosal Melanoma of the Anus: A Comprehensive Case Report.

ACG Case Rep J

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.

Published: January 2025

Anorectal mucosal melanoma (ARMM) is exceptionally rare, highly malignant, and characterized by a poor prognosis. We present the case of a 76-year-old woman with ARMM and recurrent gastrointestinal (GI) bleeding/anemia caused by small-bowel metastases, which was successfully managed with laparoscopic resection. ARMM is an aggressive type of cancer that has the potential to metastasize to the GI tract approximately 4.5 years after the primary diagnosis. Intussusception and GI bleed are potential complications. Small-bowel metastatic melanoma typically goes undiagnosed until autopsy and requires a multidisciplinary approach. Key treatment options include surgery and immunotherapy to improve patient outcomes.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671065PMC
http://dx.doi.org/10.14309/crj.0000000000001577DOI Listing

Publication Analysis

Top Keywords

small-bowel metastatic
8
metastatic melanoma
8
mucosal melanoma
8
melanoma
4
melanoma primary
4
primary mucosal
4
melanoma anus
4
anus comprehensive
4
comprehensive case
4
case report
4

Similar Publications

The Black Esophagus: A Rare Case Presentation.

Cureus

December 2024

Gastroenterology and Hepatology, Saint Peter's University Hospital, New Brunswick, USA.

Acute esophageal necrosis (AEN), also known as black esophagus or Gurvits syndrome, is an uncommon endoscopic finding characterized by diffuse, circumferential, black discoloration of the esophagus that terminates at the gastroesophageal junction. The incidence of AEN has been reported to be 0-0.2% in autopsy series and up to 0.

View Article and Find Full Text PDF

Purpose: This study aimed to analyze the characteristics and outcomes of patients with an aortoduodenal fistula (ADF) who underwent surgical treatment at a single institution.

Materials And Methods: The data of patients diagnosed with ADF at the Yonsei University Gangnam Severance Hospital, South Korea, between 2019 and 2022 were included. Primary repair and segmental resection of the duodenum with duodeno-jejunostomy were the two main methods used to repair ADF.

View Article and Find Full Text PDF

Douglas abscesses (DA) involving the ovaries and/or fallopian tubes and tubo-ovarian abscesses (TOA) constitute a very rare finding in virginal females. Underlying conditions are suspected to play a role in their development; often however, the exact pathomechanism remains hypothetical or unknown. We report the case of a 19-year-old virginal female who was referred to our outpatient clinic for further clarification of a 6-month ongoing secondary amenorrhea.

View Article and Find Full Text PDF

Gut microbiota prevents small intestinal tumor formation due to bile acids in gnotobiotic mice.

Microbiome Res Rep

August 2024

Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen 52074, Germany.

The gut microbiota is implicated in the development of intestinal tumors. Furthermore, Western diet is a risk factor for colorectal cancer and induces alterations in both the microbiota and bile acid metabolism. Therefore, we aimed to investigate the causal role of Western diet-induced changes in the microbiota and secondary bile acid production, which were linked to disease exacerbation in pigs.

View Article and Find Full Text PDF

Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study.

BMC Gastroenterol

December 2024

Department of Gastroenterology and Hepatology, Linkou Branch, Chang Gung Memorial Hospital, 5, Fu-Hsin Street, Guei-Shan District, Taoyuan, 33305, Taiwan.

Background/aims: The increasing use of biologic therapies for moderate to severe inflammatory bowel disease (IBD) highlights the importance of optimal treatment sequencing, particularly after vedolizumab (VDZ) exposure. Studies comparing the effectiveness of ustekinumab (UST) and antitumor necrosis factor (anti-TNF) agents post-VDZ are limited.

Methods: This retrospective study analyzed VDZ-experienced IBD patients treated with UST or anti-TNF (adalimumab and infliximab) from May 2019 to January 2024.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!