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Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate.
Biomed Pharmacother
March 2024
Center for Redox Biology & Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan, Hubei Province, China; Department of Child Health Care, Hubei Maternity and Child Health Care Hospital, Wuhan, Hubei Province, China; Cooperative Innovation Center of Industrial Fermentation, Ministry of Education & Hubei Province, Hubei University of Technology, Wuhan, Hubei Province, China. Electronic address:
Article Synopsis
- This study investigates the levels of folate receptor autoantibody (FRAA) in children with autism spectrum disorder (ASD) compared to typically-developing (TD) children, finding lower levels of FRAA in the ASD group, particularly among boys.
- Researchers also assessed serum levels of folate, vitamin B, and ferritin, revealing no significant differences in folate levels between the two groups, but noted specific differences in boys.
- The study suggests the potential diagnostic value of combining nitrite and binding-FRAA for ASD, highlighting that low FRAA levels in autistic children may be influenced by various factors, warranting further research.
The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been associated with autism spectrum disorders (ASD) and is treated with -leucovorin (folinic acid). One cause of CFD is an autoantibody that interferes with the function of the FRα.
View Article and Find Full Text PDFFolic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Cells
August 2021
Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University "Our Lady of Good Counsel", Rruga Dritan Hoxha, 1000 Tirana, Albania.
Folic acid has been identified to be integral in rapid tissue growth and cell division during fetal development. Different studies indicate folic acid's importance in improving childhood behavioral outcomes and underline its role as a modifiable risk factor for autism spectrum disorders. The aim of this systematic review is to both elucidate the potential role of folic acid in autism spectrum disorders and to investigate the mechanisms involved.
View Article and Find Full Text PDF[Neural network: A future in pathology?].
Ann Pathol
April 2019
ENSMM, CNR, FEMTO-ST institute, université de Bourgogne Franche-Comté, 25000 Besançon, France. Electronic address:
Artificial Intelligence, in particular deep neural networks are the most used machine learning technics in the biomedical field. Artificial neural networks are inspired by the biological neurons; they are interconnected and follow mathematical models. Two phases are required: a learning and a using phase.
View Article and Find Full Text PDFHigh prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders.
Biomarkers
November 2018
i Shanghai Key Laboratory of Birth Defects , Xiamen Branch of Children's Hospital of Fudan University(Xiamen Children's Hospital), Children's Hospital of Fudan University, Shanghai , China.
Background: Supplementation of folic acid by pregnant mothers is thought to lower the risk of autism spectrum disorders (ASDs) in the offspring. Folic acid is taken up by cells via receptors with high affinity for folate and reduced folic acid derivatives. However, this is blocked by the presence of folate receptor autoantibodies (FRAA).
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