Prioritising Relevant Polychlorinated Naphthalene (PCN) Congeners for Human Dietary Exposure Studies.

Following a decline in the production and use of polychlorinated naphthalenes (PCNs) and the restrictions introduced by the Stockholm Convention, dietary intake represents the most significant pathway of human exposure to these dioxin-like contaminants. PCNs occur ubiquitously in foods, originating from the legacy of historical production that is now globally redistributed, as well as from ongoing industrial and domestic combustion sources which have a stronger influence on occurrence patterns in countries where they were not produced. Recent studies have benefited from a wider set of available PCN reference standards, enabling more accurate reporting of a diverse range of congeners. Combining the available information on food occurrence with relative potency (REP) data, an initial selection of twenty PCN congeners are presented here for monitoring of foodstuffs. The selection is expected to provide a good indication of the overall dioxin-like toxic equivalence (TEQ) associated with food occurrence, particularly in industrialised countries and regions where both, historical production and current combustion are significant sources. The selection also appears to be representative of the vast majority of PCN TEQ reported in human tissues despite the limited amount of reliable data. Future studies will benefit from the increasing availability of new PCN standards and provide a broader spectrum of occurrence data in foods and human tissues. They will also support toxicological studies on a wider range of congeners and biological effects, enhancing our understanding of PCN-mediated toxicity. Both these information strands will allow refinement and expansion of the proposed selection of congeners, if required.